Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease

The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tig...

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Detalles Bibliográficos
Autores: Hionides Gutiérrez, Alejandro, Mazariegos, Marina S., Alemany, Susana, Nevzorova, Yulia, Cubero Palero, Francisco Javier, Sanz García, Carlos
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/101373
Acceso en línea:https://hdl.handle.net/20.500.14352/101373
Access Level:acceso abierto
Palabra clave:616-006.04
612.017
MAPK
Cancer osaka thyroid
Tumor progression locus- 2
cancer
inflammation
chronic liver disease
Ciencias Biomédicas
Inmunología
24 Ciencias de la Vida
2412 Inmunología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/101373
network_acronym_str ES
network_name_str España
repository_id_str
spelling Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver diseaseHionides Gutiérrez, AlejandroMazariegos, Marina S.Alemany, SusanaNevzorova, YuliaCubero Palero, Francisco JavierSanz García, Carlos616-006.04612.017MAPKCancer osaka thyroidTumor progression locus- 2cancerinflammationchronic liver diseaseCiencias BiomédicasInmunología24 Ciencias de la Vida2412 InmunologíaThe cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.ElsevierUniversidad Complutense de Madrid20232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/101373reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1013732026-06-02T12:44:21Z
dc.title.none.fl_str_mv Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
title Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
spellingShingle Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
Hionides Gutiérrez, Alejandro
616-006.04
612.017
MAPK
Cancer osaka thyroid
Tumor progression locus- 2
cancer
inflammation
chronic liver disease
Ciencias Biomédicas
Inmunología
24 Ciencias de la Vida
2412 Inmunología
title_short Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
title_full Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
title_fullStr Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
title_full_unstemmed Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
title_sort Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
dc.creator.none.fl_str_mv Hionides Gutiérrez, Alejandro
Mazariegos, Marina S.
Alemany, Susana
Nevzorova, Yulia
Cubero Palero, Francisco Javier
Sanz García, Carlos
author Hionides Gutiérrez, Alejandro
author_facet Hionides Gutiérrez, Alejandro
Mazariegos, Marina S.
Alemany, Susana
Nevzorova, Yulia
Cubero Palero, Francisco Javier
Sanz García, Carlos
author_role author
author2 Mazariegos, Marina S.
Alemany, Susana
Nevzorova, Yulia
Cubero Palero, Francisco Javier
Sanz García, Carlos
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04
612.017
MAPK
Cancer osaka thyroid
Tumor progression locus- 2
cancer
inflammation
chronic liver disease
Ciencias Biomédicas
Inmunología
24 Ciencias de la Vida
2412 Inmunología
topic 616-006.04
612.017
MAPK
Cancer osaka thyroid
Tumor progression locus- 2
cancer
inflammation
chronic liver disease
Ciencias Biomédicas
Inmunología
24 Ciencias de la Vida
2412 Inmunología
description The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/101373
url https://hdl.handle.net/20.500.14352/101373
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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