Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease
The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tig...
| Authors: | , , , , , |
|---|---|
| Format: | article |
| Publication Date: | 2023 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/101373 |
| Online Access: | https://hdl.handle.net/20.500.14352/101373 |
| Access Level: | Open access |
| Keyword: | 616-006.04 612.017 MAPK Cancer osaka thyroid Tumor progression locus- 2 cancer inflammation chronic liver disease Ciencias Biomédicas Inmunología 24 Ciencias de la Vida 2412 Inmunología |
| Summary: | The cytoplasmic protein tumor progression locus 2 (TPL2), also known as cancer Osaka thyroid (Cot), or MAP3K8, is thought to have a significant role in a variety of cancers and illnesses and it is a key component in the activation pathway for the expression of inflammatory mediators. Despite the tight connection between inflammation and TPL2, its function has not been extensively studied in chronic liver disease (CLD), a major cause of morbidity and mortality worldwide. Here, we analyze more in detail the significance of TPL2 in CLD to shed light on the pathological and molecular transduction pattern of TPL2 during the progression of CLD. This might result in important advancements and enable progress in the diagnosis and treatment of CLD. |
|---|