Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence
Background: Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods: Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/189441 |
| Acesso em linha: | https://hdl.handle.net/2445/189441 |
| Access Level: | acceso abierto |
| Palavra-chave: | Tumors Càncer de pulmó Biòpsia Broncoscòpia Lung cancer Biopsy Bronchoscopy |
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Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrenceCañizares, M.A.Matilla, J. M.Cueto, A.Algar, J.Muguruza, I.Moreno-Mata, N.Moreno-Balsalobre, R.Guijarro, R.Arrabal, R.Garcia-Fontan, E.Gonzalez-Piñeiro, A.Garcia-Yuste, M.EMETNE-SEPAR MembersMoya Amorós, JuanTumorsCàncer de pulmóBiòpsiaBroncoscòpiaTumorsLung cancerBiopsyBronchoscopyBackground: Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods: Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results: In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions: Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome.BMJ Publishing Group2022202220142022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttps://hdl.handle.net/2445/189441Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1136/thoraxjnl-2013-204102Thorax, 2014, vol. 69, p. 648-653https://doi.org/10.1136/thoraxjnl-2013-204102(c) BMJ Publishing Group, 2014info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1894412026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| title |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| spellingShingle |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence Cañizares, M.A. Tumors Càncer de pulmó Biòpsia Broncoscòpia Tumors Lung cancer Biopsy Bronchoscopy |
| title_short |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| title_full |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| title_fullStr |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| title_full_unstemmed |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| title_sort |
Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence |
| dc.creator.none.fl_str_mv |
Cañizares, M.A. Matilla, J. M. Cueto, A. Algar, J. Muguruza, I. Moreno-Mata, N. Moreno-Balsalobre, R. Guijarro, R. Arrabal, R. Garcia-Fontan, E. Gonzalez-Piñeiro, A. Garcia-Yuste, M. EMETNE-SEPAR Members Moya Amorós, Juan |
| author |
Cañizares, M.A. |
| author_facet |
Cañizares, M.A. Matilla, J. M. Cueto, A. Algar, J. Muguruza, I. Moreno-Mata, N. Moreno-Balsalobre, R. Guijarro, R. Arrabal, R. Garcia-Fontan, E. Gonzalez-Piñeiro, A. Garcia-Yuste, M. EMETNE-SEPAR Members Moya Amorós, Juan |
| author_role |
author |
| author2 |
Matilla, J. M. Cueto, A. Algar, J. Muguruza, I. Moreno-Mata, N. Moreno-Balsalobre, R. Guijarro, R. Arrabal, R. Garcia-Fontan, E. Gonzalez-Piñeiro, A. Garcia-Yuste, M. EMETNE-SEPAR Members Moya Amorós, Juan |
| author2_role |
author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Tumors Càncer de pulmó Biòpsia Broncoscòpia Tumors Lung cancer Biopsy Bronchoscopy |
| topic |
Tumors Càncer de pulmó Biòpsia Broncoscòpia Tumors Lung cancer Biopsy Bronchoscopy |
| description |
Background: Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods: Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results: In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions: Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/189441 |
| url |
https://hdl.handle.net/2445/189441 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1136/thoraxjnl-2013-204102 Thorax, 2014, vol. 69, p. 648-653 https://doi.org/10.1136/thoraxjnl-2013-204102 |
| dc.rights.none.fl_str_mv |
(c) BMJ Publishing Group, 2014 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) BMJ Publishing Group, 2014 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BMJ Publishing Group |
| publisher.none.fl_str_mv |
BMJ Publishing Group |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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