Supplementary Information: The piper at the gates of brain: A systematic review of surface modification strategies on lipid nanoparticles to overcome the Blood-Brain-Barrier
Table S1: Comparative analysis of BBB penetration by studies of lipid nanoparticles, both unmodified and modified with commonly used materials such as surfactants or PEGylated lipids. -- Figure S1. Graphical illustration of the distribution of studies with lipid nanoparticles unmodified or modified...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/384712 |
| Acceso en línea: | http://hdl.handle.net/10261/384712 |
| Access Level: | acceso abierto |
| Palabra clave: | Active targeting Brain delivery Nanoparticle decoration Nanoparticle functionalization Functionalization strategies Receptor targeting Ligand selection |
| Sumario: | Table S1: Comparative analysis of BBB penetration by studies of lipid nanoparticles, both unmodified and modified with commonly used materials such as surfactants or PEGylated lipids. -- Figure S1. Graphical illustration of the distribution of studies with lipid nanoparticles unmodified or modified with regularly used materials such as surfactants or PEGylated lipids. -- Figure S2. Scree plot for principal component analysis of studies with permeation enhancement ratio. -- Figure S3. Score plot for principal component analysis of studies with permeation enhancement ratio. -- Figure S4. Loading plot for principal component analysis of studies with permeation enhancement ratio. -- Figure S5-A: Classification and Regression tree (CART®) for permeation enhancement ratio, particle size, type of lipid nanoparticle, and category of functionalization, nodes 1 to 13, terminal nodes 1, 6 to 11. -- Figure S5-B: Classification and Regression tree (CART®) for permeation enhancement ratio, particle size, type of lipid nanoparticle and category of functionalization, nodes 6 to 9, and terminal nodes 2 to 6. -- Figure S5-C: Classification and Regression tree (CART®) for permeation enhancement ratio, particle size, type of lipid nanoparticle, and category of functionalization, nodes 14 to 16, and terminal nodes 12 to 16. -- Figure S6. Chart of relative variable importance for the Classification and Regression tree (CART®) for permeation enhancement ratio, particle size, type of lipid nanoparticle, and category of functionalization. -- Figure S7. Scatterplot for particle size and permeation enhancement ratio. -- Figure S8. Main effects analysis of permeation enhancement ratios. |
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