Advancing through the blood-brain barrier: mechanisms, challenges and drug delivery strategies

[Background and purpose] The delivery of therapeutics to the central nervous system (CNS) remains a major challenge due to the restrictive nature of the blood-brain barrier (BBB), a key evolutionary feature that preserves brain homeostasis. This review seeks to synthesize current knowledge on BBB co...

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Detalhes bibliográficos
Autores: Vargas, Ronny, Martínez Martínez, Noelia, Lizano-Barrantes, Catalina, Pacheco-Molina, Jorge Andrés, García-Montoya, Encarna, Pérez-Lozano, Pilar, Suñé-Negre, Josep Mª, Suñé, Carlos, Suñé-Pou, Marc
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/419000
Acesso em linha:http://hdl.handle.net/10261/419000
https://api.elsevier.com/content/abstract/scopus_id/105026172164
Access Level:acceso abierto
Palavra-chave:Brain delivery
Central nervous system
Lipid nanoparticles
Targeted therapy
Descrição
Resumo:[Background and purpose] The delivery of therapeutics to the central nervous system (CNS) remains a major challenge due to the restrictive nature of the blood-brain barrier (BBB), a key evolutionary feature that preserves brain homeostasis. This review seeks to synthesize current knowledge on BBB composition, physiology, and transport mechanisms, and critically analyses drug delivery strategies aimed at overcoming this barrier and enabling effective CNS therapies.

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