Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases

Introduction: The intensity of exposure to index cases of tuberculosis [TB] may increase the risk of TB in their contacts. The aim was to determine TB risk factors among contacts of TB index cases. Methods: A cohort study was carried out in the contacts of pulmonary TB cases registered by the epidem...

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Autores: Godoy, Sofía, Parrón, Ignacio, Millet, Joan Pau, Caylà, Joan A., Follia, Núria, Carol, Monica, Orcau, Angels, Alsedà Graells, Miquel, Toledo, Diana, Plans, Pere, Ferrús, Gloria, Barrabeig, Irene, Clotet, Laura, Domínguez, Angela, Godoy i García, Pere
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Recursos:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/469389
Acesso em linha:https://doi.org/10.1016/j.annepidem.2024.01.004
https://hdl.handle.net/10459.1/469389
Access Level:acceso abierto
Palavra-chave:Contact tracing
Epidemiology
Latent tuberculosis infection
Risk factor
Tuberculosis
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spelling Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index casesGodoy, SofíaParrón, IgnacioMillet, Joan PauCaylà, Joan A.Follia, NúriaCarol, MonicaOrcau, AngelsAlsedà Graells, MiquelToledo, DianaPlans, PereFerrús, GloriaBarrabeig, IreneClotet, LauraDomínguez, AngelaGodoy i García, PereContact tracingEpidemiologyLatent tuberculosis infectionRisk factorTuberculosisIntroduction: The intensity of exposure to index cases of tuberculosis [TB] may increase the risk of TB in their contacts. The aim was to determine TB risk factors among contacts of TB index cases. Methods: A cohort study was carried out in the contacts of pulmonary TB cases registered by the epidemiological surveillance network from 01/01/2019 to 06/30/2021. The factors associated with the risk of TB in contacts were determined using the adjusted odds ratio [aOR] and its 95% confidence interval [CI]. Results: From 847 TB cases, 7087 contacts were identified. The prevalence of TB was 2.0% [145/7087] and was higher in < 5 years compared to those ≥ 65 years [4.4% versus 1.2%; p < 0.001], in those exposed ≥ 6 h daily [4%], and < 6 h daily [1.6%] with respect to weekly exposure of < 6 h [0.7%; p < 0.001]. Those contacts exposed ≥ 6 h daily [aOR= 6.9; 95%CI:2.1–22.1], < 5 years [aOR= 8.3; 95%CI:1.8–37.8] and immigrants [aOR= 1.7; 95%CI:1.1–2.7] had a higher risk of TB. Conclusions: The risk of TB increases with the time of exposure to the index case and this risk is also higher in < 5 years and immigrants. Contact tracing has a high yield for detecting new cases of TB.This study was supported by the Ministry of Science and Innovation, the Institute of Health Carlos III [Project PI18/01751] and the European Regional Development Fund. [ERDF: Una manera de hacer Europa].Elsevier2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttps://doi.org/10.1016/j.annepidem.2024.01.004https://hdl.handle.net/10459.1/469389reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01751Reproducció postprint del document publicat a https://doi.org/10.1016/j.annepidem.2024.01.004Annals of Epidemiology, 2024, vol. 91, p. 12-17cc-by-nc-nd (c) Elsevier, 2024info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0oai:repositori.udl.cat:10459.1/4693892026-06-24T12:42:17Z
dc.title.none.fl_str_mv Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
title Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
spellingShingle Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
Godoy, Sofía
Contact tracing
Epidemiology
Latent tuberculosis infection
Risk factor
Tuberculosis
title_short Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
title_full Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
title_fullStr Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
title_full_unstemmed Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
title_sort Risk of tuberculosis among pulmonary tuberculosis contacts: the importance of time of exposure to index cases
dc.creator.none.fl_str_mv Godoy, Sofía
Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Plans, Pere
Ferrús, Gloria
Barrabeig, Irene
Clotet, Laura
Domínguez, Angela
Godoy i García, Pere
author Godoy, Sofía
author_facet Godoy, Sofía
Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Plans, Pere
Ferrús, Gloria
Barrabeig, Irene
Clotet, Laura
Domínguez, Angela
Godoy i García, Pere
author_role author
author2 Parrón, Ignacio
Millet, Joan Pau
Caylà, Joan A.
Follia, Núria
Carol, Monica
Orcau, Angels
Alsedà Graells, Miquel
Toledo, Diana
Plans, Pere
Ferrús, Gloria
Barrabeig, Irene
Clotet, Laura
Domínguez, Angela
Godoy i García, Pere
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Contact tracing
Epidemiology
Latent tuberculosis infection
Risk factor
Tuberculosis
topic Contact tracing
Epidemiology
Latent tuberculosis infection
Risk factor
Tuberculosis
description Introduction: The intensity of exposure to index cases of tuberculosis [TB] may increase the risk of TB in their contacts. The aim was to determine TB risk factors among contacts of TB index cases. Methods: A cohort study was carried out in the contacts of pulmonary TB cases registered by the epidemiological surveillance network from 01/01/2019 to 06/30/2021. The factors associated with the risk of TB in contacts were determined using the adjusted odds ratio [aOR] and its 95% confidence interval [CI]. Results: From 847 TB cases, 7087 contacts were identified. The prevalence of TB was 2.0% [145/7087] and was higher in < 5 years compared to those ≥ 65 years [4.4% versus 1.2%; p < 0.001], in those exposed ≥ 6 h daily [4%], and < 6 h daily [1.6%] with respect to weekly exposure of < 6 h [0.7%; p < 0.001]. Those contacts exposed ≥ 6 h daily [aOR= 6.9; 95%CI:2.1–22.1], < 5 years [aOR= 8.3; 95%CI:1.8–37.8] and immigrants [aOR= 1.7; 95%CI:1.1–2.7] had a higher risk of TB. Conclusions: The risk of TB increases with the time of exposure to the index case and this risk is also higher in < 5 years and immigrants. Contact tracing has a high yield for detecting new cases of TB.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.annepidem.2024.01.004
https://hdl.handle.net/10459.1/469389
url https://doi.org/10.1016/j.annepidem.2024.01.004
https://hdl.handle.net/10459.1/469389
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01751
Reproducció postprint del document publicat a https://doi.org/10.1016/j.annepidem.2024.01.004
Annals of Epidemiology, 2024, vol. 91, p. 12-17
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2024
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/4.0
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2024
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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