Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response
Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site determined by 111In-labelled autologous plate...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/709316 |
| Acceso en línea: | http://hdl.handle.net/10486/709316 https://dx.doi.org/10.1111/bjh.19145 |
| Access Level: | acceso abierto |
| Palabra clave: | Immune Thrombocytopenia Platelet Glycome Platelet Sequestration Kinetic Splenectomy Medicina |
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Study of platelet kinetics in immune thrombocytopenia to predict splenectomy responseMendoza Martínez, AnaÁlvarez Roman, María TeresaMonzón Manzano, ElenaAcuña Butta, PaulaGarcía Arias-Salgado, ElenaRivas Pollmar, María IsabelMartín Salces, MónicaMartínez de Miguel, BárbaraMartínez Montalbán, ElenaJiménez Yuste, Víctor ManuelButta, Nora V.Immune ThrombocytopeniaPlatelet GlycomePlatelet Sequestration KineticSplenectomyMedicinaDespite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site determined by 111In-labelled autologous platelet scintigraphy has been proposed to predict splenectomy outcome, but without standardisation in clinical practice. Here, we conducted a single-centre study by analysing a cohort of splenectomised patients with ITP in whom 111In-scintigraphy was performed at La Paz University Hospital in Madrid to evaluate the predictive value of the platelet kinetic studies. We also studied other factors that could impact the splenectomy outcome, such as patient and platelet characteristics. A total of 51 patients were splenectomised, and 82.3% responded. The splenic sequestration pattern predicted a higher rate of complete response up to 12 months after splenectomy (p = 0.005), with 90% sensitivity and 77% specificity. Neither age, comorbidities, therapy lines nor previous response to them showed any association with response. Results from the platelet characteristics analysis revealed a significant loss of sialic acid in platelets from the non-responding patients compared with those who maintained a response (p = 0.0017). Our findings highlight the value of splenic sequestration as an independent predictor of splenectomy responseWileyDepartamento de MedicinaFacultad de Medicina20232023-10-11research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/709316https://dx.doi.org/10.1111/bjh.19145reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7093162026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| title |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| spellingShingle |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response Mendoza Martínez, Ana Immune Thrombocytopenia Platelet Glycome Platelet Sequestration Kinetic Splenectomy Medicina |
| title_short |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| title_full |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| title_fullStr |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| title_full_unstemmed |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| title_sort |
Study of platelet kinetics in immune thrombocytopenia to predict splenectomy response |
| dc.creator.none.fl_str_mv |
Mendoza Martínez, Ana Álvarez Roman, María Teresa Monzón Manzano, Elena Acuña Butta, Paula García Arias-Salgado, Elena Rivas Pollmar, María Isabel Martín Salces, Mónica Martínez de Miguel, Bárbara Martínez Montalbán, Elena Jiménez Yuste, Víctor Manuel Butta, Nora V. |
| author |
Mendoza Martínez, Ana |
| author_facet |
Mendoza Martínez, Ana Álvarez Roman, María Teresa Monzón Manzano, Elena Acuña Butta, Paula García Arias-Salgado, Elena Rivas Pollmar, María Isabel Martín Salces, Mónica Martínez de Miguel, Bárbara Martínez Montalbán, Elena Jiménez Yuste, Víctor Manuel Butta, Nora V. |
| author_role |
author |
| author2 |
Álvarez Roman, María Teresa Monzón Manzano, Elena Acuña Butta, Paula García Arias-Salgado, Elena Rivas Pollmar, María Isabel Martín Salces, Mónica Martínez de Miguel, Bárbara Martínez Montalbán, Elena Jiménez Yuste, Víctor Manuel Butta, Nora V. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
Immune Thrombocytopenia Platelet Glycome Platelet Sequestration Kinetic Splenectomy Medicina |
| topic |
Immune Thrombocytopenia Platelet Glycome Platelet Sequestration Kinetic Splenectomy Medicina |
| description |
Despite the efficacy of splenectomy for chronic immune thrombocytopenia (ITP), its considerable failure rate and its possible related complications prove the need for further research into potential predictors of response. The platelet sequestration site determined by 111In-labelled autologous platelet scintigraphy has been proposed to predict splenectomy outcome, but without standardisation in clinical practice. Here, we conducted a single-centre study by analysing a cohort of splenectomised patients with ITP in whom 111In-scintigraphy was performed at La Paz University Hospital in Madrid to evaluate the predictive value of the platelet kinetic studies. We also studied other factors that could impact the splenectomy outcome, such as patient and platelet characteristics. A total of 51 patients were splenectomised, and 82.3% responded. The splenic sequestration pattern predicted a higher rate of complete response up to 12 months after splenectomy (p = 0.005), with 90% sensitivity and 77% specificity. Neither age, comorbidities, therapy lines nor previous response to them showed any association with response. Results from the platelet characteristics analysis revealed a significant loss of sialic acid in platelets from the non-responding patients compared with those who maintained a response (p = 0.0017). Our findings highlight the value of splenic sequestration as an independent predictor of splenectomy response |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-10-11 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/709316 https://dx.doi.org/10.1111/bjh.19145 |
| url |
http://hdl.handle.net/10486/709316 https://dx.doi.org/10.1111/bjh.19145 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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