Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale
Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physica...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/54231 |
| Acceso en línea: | http://hdl.handle.net/10230/54231 http://dx.doi.org/10.3390/jcm11030672 |
| Access Level: | acceso abierto |
| Palabra clave: | FRAIL Frailty Kidney transplant waiting list |
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Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scalePérez-Sáez, María JoséRedondo Pachón, María DoloresArias Cabrales, Carlos EnriqueFaura, AnnaBach Pascual, AnnaBuxeda, AnnaBurballa Tàrrega, Carla, 1988-Junyent-Iglesias, ErnestinaCrespo Barrio, MartaMarco Navarro, EsterRodríguez-Mañas, LeocadioPascual Santos, JulioFRAILFrailtyKidney transplant waiting listFrailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.MDPI202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54231http://dx.doi.org/10.3390/jcm11030672reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJ Clin Med. 2022 Jan 28;11(3):672© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/542312026-06-12T07:21:37Z |
| dc.title.none.fl_str_mv |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| title |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| spellingShingle |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale Pérez-Sáez, María José FRAIL Frailty Kidney transplant waiting list |
| title_short |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| title_full |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| title_fullStr |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| title_full_unstemmed |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| title_sort |
Outcomes of frail patients while waiting for kidney transplantation: differences between physical frailty phenotype and FRAIL scale |
| dc.creator.none.fl_str_mv |
Pérez-Sáez, María José Redondo Pachón, María Dolores Arias Cabrales, Carlos Enrique Faura, Anna Bach Pascual, Anna Buxeda, Anna Burballa Tàrrega, Carla, 1988- Junyent-Iglesias, Ernestina Crespo Barrio, Marta Marco Navarro, Ester Rodríguez-Mañas, Leocadio Pascual Santos, Julio |
| author |
Pérez-Sáez, María José |
| author_facet |
Pérez-Sáez, María José Redondo Pachón, María Dolores Arias Cabrales, Carlos Enrique Faura, Anna Bach Pascual, Anna Buxeda, Anna Burballa Tàrrega, Carla, 1988- Junyent-Iglesias, Ernestina Crespo Barrio, Marta Marco Navarro, Ester Rodríguez-Mañas, Leocadio Pascual Santos, Julio |
| author_role |
author |
| author2 |
Redondo Pachón, María Dolores Arias Cabrales, Carlos Enrique Faura, Anna Bach Pascual, Anna Buxeda, Anna Burballa Tàrrega, Carla, 1988- Junyent-Iglesias, Ernestina Crespo Barrio, Marta Marco Navarro, Ester Rodríguez-Mañas, Leocadio Pascual Santos, Julio |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
FRAIL Frailty Kidney transplant waiting list |
| topic |
FRAIL Frailty Kidney transplant waiting list |
| description |
Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/54231 http://dx.doi.org/10.3390/jcm11030672 |
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http://hdl.handle.net/10230/54231 http://dx.doi.org/10.3390/jcm11030672 |
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Inglés |
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Inglés |
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J Clin Med. 2022 Jan 28;11(3):672 |
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https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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MDPI |
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MDPI |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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