Outcomes of Frail Patients While Waiting for Kidney Transplantation

Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physica...

Descripción completa

Detalles Bibliográficos
Autores: Pérez-Sáez, María José|||0000-0002-8601-2699, Redondo-Pachón, Dolores|||0000-0002-0458-0052, Arias Cabrales, Carlos E|||0000-0002-1729-8152, Faura, Anna|||0000-0002-1440-3922, Bach Pascual, Anna|||0000-0003-0571-6131, Buxeda, Anna|||0000-0001-7305-3259, Burballa, Carla|||0000-0002-0091-1459, Junyent, Ernestina, Crespo, Marta|||0000-0001-6992-6379, Marco, Ester|||0000-0002-3412-0356, Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333, Pascual, Julio|||0000-0002-4735-7838
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256043
Acceso en línea:https://ddd.uab.cat/record/256043
https://dx.doi.org/urn:doi:10.3390/jcm11030672
Access Level:acceso abierto
Palabra clave:Frailty
FRAIL
Kidney transplant waiting list
Descripción
Sumario:Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16.3 vs. 7.4%, p = 0.013). Robust patients had fewer hospital admissions during the 1st year after listing (20.8% if PFP = 0 vs. 43.4% if ≥1, and 27.1% if FRAIL = 0 vs. 48.9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0.45 [0.26-0.77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.

Similares en LA Referencia