Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration

The mechanisms underlying the evolution of carotenoid-based colouration as a reliable signal of individual quality are still poorly understood. The Resource Allocation Trade-off hypothesis (RATH) asserts that honesty is maintained as only good-quality individuals have enough carotenoids to invest bo...

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Autor: Ramos Chernenko, Anna
Tipo de recurso: tesis de maestría
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:dnet:digitalcsic_::88ca81ff9adbbb9c2b57fbdd495bc40e
Acceso en línea:http://hdl.handle.net/10261/426880
Access Level:acceso abierto
Palabra clave:Carotenoid-based colouration
Ketocarotenoids
Loxia curvirostra
Mitochondrial metabolism
Mito-targeted antioxidants
MitoTEMPO
Sexual selection
Shared-pathway hypothesis
Thyroid hormones
Triiodothyronine
Antioxidantes dirigidos a la mitocondria
Coloración basada en carotenoides
Hipótesis de la vía compartida
Hormonas tiroideas
Metabolismo mitocondrial
Quetocarotenoides
Selección sexual
Triyodotironina
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dc.title.none.fl_str_mv Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
title Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
spellingShingle Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
Ramos Chernenko, Anna
Carotenoid-based colouration
Ketocarotenoids
Loxia curvirostra
Mitochondrial metabolism
Mito-targeted antioxidants
MitoTEMPO
Sexual selection
Shared-pathway hypothesis
Thyroid hormones
Triiodothyronine
Antioxidantes dirigidos a la mitocondria
Coloración basada en carotenoides
Hipótesis de la vía compartida
Hormonas tiroideas
Loxia curvirostra
Metabolismo mitocondrial
MitoTEMPO
Quetocarotenoides
Selección sexual
Triyodotironina
title_short Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
title_full Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
title_fullStr Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
title_full_unstemmed Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
title_sort Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colouration
dc.creator.none.fl_str_mv Ramos Chernenko, Anna
author Ramos Chernenko, Anna
author_facet Ramos Chernenko, Anna
author_role author
dc.contributor.none.fl_str_mv Cantarero, Alejandro
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Carotenoid-based colouration
Ketocarotenoids
Loxia curvirostra
Mitochondrial metabolism
Mito-targeted antioxidants
MitoTEMPO
Sexual selection
Shared-pathway hypothesis
Thyroid hormones
Triiodothyronine
Antioxidantes dirigidos a la mitocondria
Coloración basada en carotenoides
Hipótesis de la vía compartida
Hormonas tiroideas
Loxia curvirostra
Metabolismo mitocondrial
MitoTEMPO
Quetocarotenoides
Selección sexual
Triyodotironina
topic Carotenoid-based colouration
Ketocarotenoids
Loxia curvirostra
Mitochondrial metabolism
Mito-targeted antioxidants
MitoTEMPO
Sexual selection
Shared-pathway hypothesis
Thyroid hormones
Triiodothyronine
Antioxidantes dirigidos a la mitocondria
Coloración basada en carotenoides
Hipótesis de la vía compartida
Hormonas tiroideas
Loxia curvirostra
Metabolismo mitocondrial
MitoTEMPO
Quetocarotenoides
Selección sexual
Triyodotironina
description The mechanisms underlying the evolution of carotenoid-based colouration as a reliable signal of individual quality are still poorly understood. The Resource Allocation Trade-off hypothesis (RATH) asserts that honesty is maintained as only good-quality individuals have enough carotenoids to invest both in vital functions and ornamentation. Individuals would face a fitness cost when investing more in signalling. The Shared-Pathway hypothesis (SPH), in contrast, upholds that the honesty of some signals (not only carotenoid-based) rely on biochemical pathways shared between the signal production and homeostasis, making the signal unfalsifiable. Here, no resource allocation trade-off would be involved and no cost of signal production would have promoted signal evolution. The Inner Mitochondrial Membrane hypothesis (IMMH) is a specific case of the shared-pathway hypothesis. Red carotenoids in many species are produced by oxidizing yellow dietary carotenoids by enzymes (ketolases). The oxidative process would be made by enzymes placed in the inner mitochondria sharing its activity with cell respiration. Early studies suggested that birds in captivity lost its red carotenoid-produced plumage due to a decline in the oxidative metabolism. To prove the link among both processes, we performed a two-factorial experiment on captive male red crossbills (Loxia curvirostra). Half of the birds were treated with subcutaneous implants filled with triiodothyronine (T3-treated birds) or empty (hormone-controls). T3 is a hormone with known hypermetabolic effects. Also, half of the birds in each group were injected with mitoTEMPO (mitoTEMPO-treated birds), a mito-targeted antioxidant designed to penetrate the IMM, or vehicle (antioxidant controls). The hormone reduced plumage redness, perhaps due to the high production of reactive oxygen species (ROS) often demonstrated under high T3 levels. These ROS would have interfered the enzymatic activity involved in carotenoid biosynthesis. MitoTEMPO, instead, did not induce a significant effect on coloration, contradicting a recent study in the same species. Differences in diet composition between both studies and/or oxidative stress derived from subcutaneous implant rejection could explain this discrepancy. We suggest that the resource trade-off hypothesis and the shared-pathway hypothesis could not be mutually exclusive.
publishDate 2020
dc.date.none.fl_str_mv 2020
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/426880
url http://hdl.handle.net/10261/426880
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spelling Triiodothyronine (T3) effect on red crossbill (Loxia curvirostra) colourationRamos Chernenko, AnnaCarotenoid-based colourationKetocarotenoidsLoxia curvirostraMitochondrial metabolismMito-targeted antioxidantsMitoTEMPOSexual selectionShared-pathway hypothesisThyroid hormonesTriiodothyronineAntioxidantes dirigidos a la mitocondriaColoración basada en carotenoidesHipótesis de la vía compartidaHormonas tiroideasLoxia curvirostraMetabolismo mitocondrialMitoTEMPOQuetocarotenoidesSelección sexualTriyodotironinaThe mechanisms underlying the evolution of carotenoid-based colouration as a reliable signal of individual quality are still poorly understood. The Resource Allocation Trade-off hypothesis (RATH) asserts that honesty is maintained as only good-quality individuals have enough carotenoids to invest both in vital functions and ornamentation. Individuals would face a fitness cost when investing more in signalling. The Shared-Pathway hypothesis (SPH), in contrast, upholds that the honesty of some signals (not only carotenoid-based) rely on biochemical pathways shared between the signal production and homeostasis, making the signal unfalsifiable. Here, no resource allocation trade-off would be involved and no cost of signal production would have promoted signal evolution. The Inner Mitochondrial Membrane hypothesis (IMMH) is a specific case of the shared-pathway hypothesis. Red carotenoids in many species are produced by oxidizing yellow dietary carotenoids by enzymes (ketolases). The oxidative process would be made by enzymes placed in the inner mitochondria sharing its activity with cell respiration. Early studies suggested that birds in captivity lost its red carotenoid-produced plumage due to a decline in the oxidative metabolism. To prove the link among both processes, we performed a two-factorial experiment on captive male red crossbills (Loxia curvirostra). Half of the birds were treated with subcutaneous implants filled with triiodothyronine (T3-treated birds) or empty (hormone-controls). T3 is a hormone with known hypermetabolic effects. Also, half of the birds in each group were injected with mitoTEMPO (mitoTEMPO-treated birds), a mito-targeted antioxidant designed to penetrate the IMM, or vehicle (antioxidant controls). The hormone reduced plumage redness, perhaps due to the high production of reactive oxygen species (ROS) often demonstrated under high T3 levels. These ROS would have interfered the enzymatic activity involved in carotenoid biosynthesis. MitoTEMPO, instead, did not induce a significant effect on coloration, contradicting a recent study in the same species. Differences in diet composition between both studies and/or oxidative stress derived from subcutaneous implant rejection could explain this discrepancy. We suggest that the resource trade-off hypothesis and the shared-pathway hypothesis could not be mutually exclusive.Actualmente se desconocen todos los mecanismos próximos implicados en la evolución de la coloración basada en carotenoides como señal fiable de la calidad individual. La hipótesis de redistribución de recursos propone que la fiabilidad de la señal se mantiene porque sólo los individuos de buena calidad tienen suficientes carotenoides para invertir tanto en las funciones vitales como en la ornamentación. Al invertir más en la señalización encararían un coste en términos de fitness (coste reproductivo o de supervivencia). Por el contrario, la hipótesis de la vía compartida sostiene que la fiabilidad de algunas señales (no sólo de las basadas en los carotenoides) descansa en rutas bioquímicas compartidas entre la producción de la señal y la homeostasis. Dichas rutas hacen que la señal se vuelva infalsificable. En este caso no estaría involucrada la distribución de recursos entre funciones en competencia, y la evolución de la señal no estaría promovida por el coste de producción de ésta. La hipótesis de la membrana mitocondrial interna es un caso específico de la hipótesis de la vía compartida. En muchas especies, los carotenoides rojos son producidos por medio de enzimas oxidativas (quetolasas) a partir de carotenoides amarillos ingeridos con la dieta. Este proceso oxidativo podría ser desempeñado por enzimas situadas en la membrana mitocondrial interna, interfiriendo con la respiración celular. Algún autor sugirió que las aves en cautividad perdían su plumaje rojizo basado en carotenoides debido a un descenso en el metabolismo oxidativo. Para probar el nexo entre ambos procesos, hemos aplicado un diseño experimental con dos factores en machos adultos de piquituerto común (Loxia curvirostra). La mitad de las aves fueron sometidas a implantes subcutáneos rellenos de triiodotironina (T3) o vacíos (controles hormonales). La T3 es una hormona con conocidos efectos hipermetabólicos. Además, la mitad de las aves de cada grupo fueron inyectadas con mitoTEMPO, un antioxidante que ha sido diseñado para penetrar en la membrana mitocondrial interna, bien o sólo con vehículo (controles del antioxidante). La hormona redujo la rojez del plumaje, tal vez mediante una alta producción de especies reactivas de oxígeno (ERO). Dicho efecto sobre el estrés oxidativo ha sido demostrado en otros vertebrados expuestos a altos niveles de T3. Estas ERO habrían interferido con la actividad enzimática involucrada en la biosíntesis de los carotenoides. El mitoTEMPO en cambio, no indujo un efecto significativo en la coloración, contradiciendo un reciente estudio experimental en la misma especie. La discrepancia podría explicarse por diferencias en la composición de la dieta entre ambos experimentos y/o el estrés oxidativo derivado del rechazo del implante subcutáneo detectado en muchos individuos. Nosotros sugerimos que la hipótesis de redistribución de recursos y la hipótesis de la vía compartida, podrían ser mutuamente no excluyentes.Universidad Complutense de Madrid; CSIC - Museo Nacional de Ciencias Naturales (MNCN)Cantarero, AlejandroMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620202026info:eu-repo/semantics/masterThesishttp://purl.org/coar/resource_type/c_bdcchttp://hdl.handle.net/10261/426880reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//CGL2015-69338-C2-2-Pinfo:eu-repo/grantAgreement/MICIU/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PGC2018-095066-B-I00Síinfo:eu-repo/semantics/openAccessoai:dnet:digitalcsic_::88ca81ff9adbbb9c2b57fbdd495bc40e2026-05-22T06:33:51Z
score 15.811543

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