BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis

BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases....

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Autores: Prieto Peña, Diana, Genre, Fernanda, Remuzgo Martínez, Sara, Pulito Cueto, Verónica, Atienza Mateo, Belén, Llorca, Javier, Sevilla Pérez, Belén, Ortego Centeno, Norberto, Lera Gómez, Leticia, Leonardo, María Teresa, Peñalba, Ana, Narváez García, Francisco Javier, Martín Penagos, Luis, Rodrigo, Emilio, Miranda Filloy, José A., Caminal Montero, Luis, Collado, Paz, Sánchez Pérez, Javier, Argila, Diego de, Rubio, Esteban, Luque, Manuel León, Blanco Madrigal, Juan María, Galíndez Agirregoikoa, Eva, Gualillo, Oreste, Martín, Javier, Castañeda, Santos, Blanco, Ricardo, González Gay, Miguel A., López Mejías, Raquel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/178993
Acesso em linha:https://hdl.handle.net/2445/178993
Access Level:acceso abierto
Palavra-chave:Immunoglobulines
Vasculitis
Malalties autoimmunitàries
Immunoglobulins
Autoimmune diseases
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spelling BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitisPrieto Peña, DianaGenre, FernandaRemuzgo Martínez, SaraPulito Cueto, VerónicaAtienza Mateo, BelénLlorca, JavierSevilla Pérez, BelénOrtego Centeno, NorbertoLera Gómez, LeticiaLeonardo, María TeresaPeñalba, AnaNarváez García, Francisco JavierMartín Penagos, LuisRodrigo, EmilioMiranda Filloy, José A.Caminal Montero, LuisCollado, PazSánchez Pérez, JavierArgila, Diego deRubio, EstebanLuque, Manuel LeónBlanco Madrigal, Juan MaríaGalíndez Agirregoikoa, EvaGualillo, OresteMartín, JavierCastañeda, SantosBlanco, RicardoGonzález Gay, Miguel A.López Mejías, RaquelImmunoglobulinesVasculitisMalalties autoimmunitàriesImmunoglobulinsVasculitisAutoimmune diseasesBAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.Springer Science and Business Media LLC2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/178993Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-021-91055-zScientific Reports, 2021, vol. 11, num. 11510https://doi.org/10.1038/s41598-021-91055-zinfo:eu-repo/grantAgreement/EC/H2020/734899cc by (c) Prieto Peña, Diana et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1789932026-05-29T05:05:01Z
dc.title.none.fl_str_mv BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
title BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
spellingShingle BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
Prieto Peña, Diana
Immunoglobulines
Vasculitis
Malalties autoimmunitàries
Immunoglobulins
Vasculitis
Autoimmune diseases
title_short BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
title_full BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
title_fullStr BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
title_full_unstemmed BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
title_sort BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin-A vasculitis
dc.creator.none.fl_str_mv Prieto Peña, Diana
Genre, Fernanda
Remuzgo Martínez, Sara
Pulito Cueto, Verónica
Atienza Mateo, Belén
Llorca, Javier
Sevilla Pérez, Belén
Ortego Centeno, Norberto
Lera Gómez, Leticia
Leonardo, María Teresa
Peñalba, Ana
Narváez García, Francisco Javier
Martín Penagos, Luis
Rodrigo, Emilio
Miranda Filloy, José A.
Caminal Montero, Luis
Collado, Paz
Sánchez Pérez, Javier
Argila, Diego de
Rubio, Esteban
Luque, Manuel León
Blanco Madrigal, Juan María
Galíndez Agirregoikoa, Eva
Gualillo, Oreste
Martín, Javier
Castañeda, Santos
Blanco, Ricardo
González Gay, Miguel A.
López Mejías, Raquel
author Prieto Peña, Diana
author_facet Prieto Peña, Diana
Genre, Fernanda
Remuzgo Martínez, Sara
Pulito Cueto, Verónica
Atienza Mateo, Belén
Llorca, Javier
Sevilla Pérez, Belén
Ortego Centeno, Norberto
Lera Gómez, Leticia
Leonardo, María Teresa
Peñalba, Ana
Narváez García, Francisco Javier
Martín Penagos, Luis
Rodrigo, Emilio
Miranda Filloy, José A.
Caminal Montero, Luis
Collado, Paz
Sánchez Pérez, Javier
Argila, Diego de
Rubio, Esteban
Luque, Manuel León
Blanco Madrigal, Juan María
Galíndez Agirregoikoa, Eva
Gualillo, Oreste
Martín, Javier
Castañeda, Santos
Blanco, Ricardo
González Gay, Miguel A.
López Mejías, Raquel
author_role author
author2 Genre, Fernanda
Remuzgo Martínez, Sara
Pulito Cueto, Verónica
Atienza Mateo, Belén
Llorca, Javier
Sevilla Pérez, Belén
Ortego Centeno, Norberto
Lera Gómez, Leticia
Leonardo, María Teresa
Peñalba, Ana
Narváez García, Francisco Javier
Martín Penagos, Luis
Rodrigo, Emilio
Miranda Filloy, José A.
Caminal Montero, Luis
Collado, Paz
Sánchez Pérez, Javier
Argila, Diego de
Rubio, Esteban
Luque, Manuel León
Blanco Madrigal, Juan María
Galíndez Agirregoikoa, Eva
Gualillo, Oreste
Martín, Javier
Castañeda, Santos
Blanco, Ricardo
González Gay, Miguel A.
López Mejías, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Immunoglobulines
Vasculitis
Malalties autoimmunitàries
Immunoglobulins
Vasculitis
Autoimmune diseases
topic Immunoglobulines
Vasculitis
Malalties autoimmunitàries
Immunoglobulins
Vasculitis
Autoimmune diseases
description BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants were analysed independently. Likewise, no statistically significant differences were found in the genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations. Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic network underlying IgAV.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178993
url https://hdl.handle.net/2445/178993
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-91055-z
Scientific Reports, 2021, vol. 11, num. 11510
https://doi.org/10.1038/s41598-021-91055-z
info:eu-repo/grantAgreement/EC/H2020/734899
dc.rights.none.fl_str_mv cc by (c) Prieto Peña, Diana et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Prieto Peña, Diana et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424911486812160
score 15,812429

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