Microencapsulación de ciprofloxacino en microesferas de albumina y liposomas (Albusomas)
[EN]Fluoroquinolones are bactericidal agents showing a broad antimicrobial spectrum used for several infectious diseases. Liposomes are excellent carriers for controlled drug delivery and albumin shows a great capacity for binding and transport of solutes. The aim of this study was to incorporate ci...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/136098 |
| Acceso en línea: | http://hdl.handle.net/10366/136098 |
| Access Level: | acceso abierto |
| Palabra clave: | liposomes ciprofloxacin albumin microencapsulation liposomas ciprofloxacino albúmina microencapsulación |
| Sumario: | [EN]Fluoroquinolones are bactericidal agents showing a broad antimicrobial spectrum used for several infectious diseases. Liposomes are excellent carriers for controlled drug delivery and albumin shows a great capacity for binding and transport of solutes. The aim of this study was to incorporate ciprofloxacin into a formulation based on the combination of liposomes and albumin in order to gather the advantages of both components into a single pharmaceutical vehicle. Liposomes were prepared by sonication, in absence of organic solvents, by using ciprofloxacin solutions of different concentration. The albusomes were prepared by mixing these with bovine serum albumin. The influence of three variables on the drug encapsulation efficiency was evaluated: liposomes composition, ciprofloxacin concentration and albumin amount; an HPLC technique was used for drug quantification. The results of the study reveal that liposomes composition significantly affects the entrapment efficiency registered while ciprofloxacin concentration does not affect this parameter. |
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