Incorporación de agentes anti-infecciosos en nanopartículas metálicas de oro y chitosan
[EN]Resistance to antimicrobial agents is a serious health problem, causing great mortality in the population. This makes very interesting the search for alternatives for the treatment of these infections caused by multiresistant bacteria. One of them could be the use of gold metallic nanoparticles...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:gredos.usal.es:10366/138971 |
| Acceso en línea: | http://hdl.handle.net/10366/138971 |
| Access Level: | acceso abierto |
| Palabra clave: | nanopartículas ciprofloxacino chitosan nanoparticles ciprofloxacin |
| Sumario: | [EN]Resistance to antimicrobial agents is a serious health problem, causing great mortality in the population. This makes very interesting the search for alternatives for the treatment of these infections caused by multiresistant bacteria. One of them could be the use of gold metallic nanoparticles (NPs) together with an anti-infectious agent such as ciprofloxacin which is a broad-spectrum antibacterial drug. The objective of the study was to evaluate the behavior of gold-chitosan (Au-chitosan) NPs compared to gold-citrate (Au-citrate) NPs in the uptake of ciprofloxacin for different incubation conditions. The nanoparticles were synthesized and the anti-infectious agent incorporated at different study concentrations. By ultra-high performance liquid chromatography (UHPLC), the concentrations of ciprofloxacin incorporated into the nanoparticles were estimated. The percentage incorporation of ciprofloxacin was higher for Au-citrate nanoparticles compared to Au-chitosan nanoparticles. However, Au-citrate disadvantage form large aggregates, difficulting its good management. Au-chitosan NPs are more stable and chitosan has antibacterial activities. Thus, gold and chitosan nanoparticles could be a good vehicle for the incorporation of anti-infective agents and may even have the potential to enhance their antimicrobial activity. |
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