Encapsulation of folic acid in different silica porous supports: A comparative study

Although folic acid is essential to numerous bodily functions, recent research indicates that a massive exposition to the vitamin could be a double-edged sword. In this study, the capacity of different caped mesoporous silica particles (i.e. Hollow Silica Shells, MCM-41, SBA-15 and UVM-7) to dose FA...

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Bibliographic Details
Authors: Pérez-Esteve, Édgar|||0000-0002-0452-1394, Villaescusa Alonso, Luis Angel|||0000-0002-2720-3217, Sancenón Galarza, Félix|||0000-0002-5205-7135, Marcos Martínez, María Dolores|||0000-0001-7079-8589, Martínez-Máñez, Ramón|||0000-0001-5873-9674, Barat Baviera, José Manuel|||0000-0001-8487-7114, Ruiz Rico, María, De la Torre Paredes, Cristina, Amoros del Toro, Pedro Jose
Format: article
Publication Date:2016
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/62330
Online Access:https://riunet.upv.es/handle/10251/62330
Access Level:Open access
Keyword:Folic acid
Porous silica supports
Smart delivery
Nutrition
Optimization
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
TECNOLOGIA DE ALIMENTOS
QUIMICA ORGANICA
INGENIERIA DE LA CONSTRUCCION
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Summary:Although folic acid is essential to numerous bodily functions, recent research indicates that a massive exposition to the vitamin could be a double-edged sword. In this study, the capacity of different caped mesoporous silica particles (i.e. Hollow Silica Shells, MCM-41, SBA-15 and UVM-7) to dose FA during its passage through the gastrointestinal tract has been evaluated. Results confirmed that the four capped materials were capable to hinder the delivery of FA at low pH (i.e. stomach) as well as able to deliver great amounts of the vitamin at neutral pH (i.e. intestine). Nevertheless, the encapsulation efficiency and the deliver kinetics differed among supports. While supports with large pore entrance exhibited an initial fast release, MCM-41, showed a sustained release along the time. This correlation between textural properties and release kinetics for each of the supports reveals the importance of a proper support selection as a strategy to control the delivery of active molecules.

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