Stability of different mesoporous silica particles during an in vitro digestion

Mesoporous silica materials have the ability to entrap drugs, nutrients and functional biomolecules and can be able to act as smart delivery systems capable to control and target the release of their cargo in a particular part of the gastrointestinal tract when administrated orally. However, the apt...

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Bibliographic Details
Authors: Pérez-Esteve, Édgar|||0000-0002-0452-1394, Llorca Martínez, Mª Empar|||0000-0003-3346-3135, Sancenón Galarza, Félix|||0000-0002-5205-7135, Marcos Martínez, María Dolores|||0000-0001-7079-8589, Martínez-Máñez, Ramón|||0000-0001-5873-9674, Barat Baviera, José Manuel|||0000-0001-8487-7114, Ruiz Rico, María, Torre, Cristina De la, Amoros del Toro, Pedro Jose, Guillen Villar, Carmen
Format: article
Publication Date:2016
Country:España
Institution:Universitat Politècnica de València (UPV)
Repository:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Language:English
OAI Identifier:oai:riunet.upv.es:10251/78699
Online Access:https://riunet.upv.es/handle/10251/78699
Access Level:Open access
Keyword:Mesoporous silica particles
In vitro digestion
Stability
Amine-functionalization
Electron Microscopy Service of the UPV
QUIMICA INORGANICA
TECNOLOGIA DE ALIMENTOS
QUIMICA ORGANICA
QUIMICA ANALITICA
INGENIERIA DE LA CONSTRUCCION
Description
Summary:Mesoporous silica materials have the ability to entrap drugs, nutrients and functional biomolecules and can be able to act as smart delivery systems capable to control and target the release of their cargo in a particular part of the gastrointestinal tract when administrated orally. However, the aptness of these encapsulation supports in in vivo oral controlled release relies on their chemical stability through the digestive tube. In this context, we have evaluated the stability of four different mesoporous silica particles, frequently used as encapsulating supports, during an in vitro digestion process comprising buccal, stomach and intestinal phases. Results showed that after 4 h of digestion, the textural properties of silica supports in the form of nanoparticles (MCM-41 and UVM-7 nanoparticles) were lost in varying degrees, whereas silica microparticles supports (MCM-41 and SBA-15 microparticles) endures better the digestion process. Moreover, the functionalization of the surface with N-1-(3-trimethoxysilylpropyl)diethylenetriamine, an organic moiety commonly used in the preparation of pH-responsive mesoporous silica particles, resulted in an improvement of the stability of the supports. (C) 2016 Elsevier Inc. All rights reserved.

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