Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility

Although most organisms have detoxification abilities (i.e mineralization, transformation and/or immobilization of pollutants), microorganisms, particularly bacteria, play a crucial role in biogeochemical cycles and in sustainable development of the biosphere. Next to glucosyl residues, the benzene...

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Author: Díaz, Eduardo
Format: article
Publication Date:2004
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/2134
Online Access:http://hdl.handle.net/10261/2134
Access Level:Open access
Keyword:Aromatic compounds
Catabolism
Transcriptional regulation
Metabolic engineering
id ES_f587e1d1c3841ea2dc00b89da309efb0
oai_identifier_str oai:digital.csic.es:10261/2134
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
Degradación bacteriana de contaminantes aromáticos: un paradigma de variabilidad metabólica
title Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
spellingShingle Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
Díaz, Eduardo
Aromatic compounds
Catabolism
Transcriptional regulation
Metabolic engineering
title_short Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
title_full Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
title_fullStr Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
title_full_unstemmed Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
title_sort Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatility
dc.creator.none.fl_str_mv Díaz, Eduardo
author Díaz, Eduardo
author_facet Díaz, Eduardo
author_role author
dc.subject.none.fl_str_mv Aromatic compounds
Catabolism
Transcriptional regulation
Metabolic engineering
topic Aromatic compounds
Catabolism
Transcriptional regulation
Metabolic engineering
description Although most organisms have detoxification abilities (i.e mineralization, transformation and/or immobilization of pollutants), microorganisms, particularly bacteria, play a crucial role in biogeochemical cycles and in sustainable development of the biosphere. Next to glucosyl residues, the benzene ring is the most widely distributed unit of chemical structure in nature, and many of the aromatic compounds are major environmental pollutants. Bacteria have developed strategies for obtaining energy from virtually every compound under oxic or anoxic conditions (using alternative final electron acceptors such as nitrate, sulfate, and ferric ions). Clusters of genes coding for the catabolism of aromatic compounds are usually found in mobile genetic elements, such as transposons and plasmids, which facilitate their horizontal gene transfer and, therefore, the rapid adaptation of microorganisms to new pollutants. A successful strategy for in situ bioremediation has been the combination, in a single bacterial strain or in a syntrophic bacterial consortium, of different degrading abilities with genetic traits that provide selective advantages in a given environment. The advent of high-throughput methods for DNA sequencing and analysis of gene expression (genomics) and function (proteomics), as well as advances in modelling microbial metabolism in silico, provide a global, rational approach to unravel the largely unexplored potentials of microorganisms in biotechnological processes thereby facilitating sustainable development.
publishDate 2004
dc.date.none.fl_str_mv 2004
2007
2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/2134
url http://hdl.handle.net/10261/2134
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedad Española de Microbiología
publisher.none.fl_str_mv Sociedad Española de Microbiología
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Bacterial degradation of aromatic pollutants: a paradigm of metabolic versatilityDegradación bacteriana de contaminantes aromáticos: un paradigma de variabilidad metabólicaDíaz, EduardoAromatic compoundsCatabolismTranscriptional regulationMetabolic engineeringAlthough most organisms have detoxification abilities (i.e mineralization, transformation and/or immobilization of pollutants), microorganisms, particularly bacteria, play a crucial role in biogeochemical cycles and in sustainable development of the biosphere. Next to glucosyl residues, the benzene ring is the most widely distributed unit of chemical structure in nature, and many of the aromatic compounds are major environmental pollutants. Bacteria have developed strategies for obtaining energy from virtually every compound under oxic or anoxic conditions (using alternative final electron acceptors such as nitrate, sulfate, and ferric ions). Clusters of genes coding for the catabolism of aromatic compounds are usually found in mobile genetic elements, such as transposons and plasmids, which facilitate their horizontal gene transfer and, therefore, the rapid adaptation of microorganisms to new pollutants. A successful strategy for in situ bioremediation has been the combination, in a single bacterial strain or in a syntrophic bacterial consortium, of different degrading abilities with genetic traits that provide selective advantages in a given environment. The advent of high-throughput methods for DNA sequencing and analysis of gene expression (genomics) and function (proteomics), as well as advances in modelling microbial metabolism in silico, provide a global, rational approach to unravel the largely unexplored potentials of microorganisms in biotechnological processes thereby facilitating sustainable development.Aunque la mayoría de los organismos pueden detoxificar el ambiente (mediante procesos de mineralización, transformación y/o inmovilización de los contaminantes), los microorganismos, especialmente las bacterias, desempeñan un papel esencial en los ciclos biogeoquímicos y en el desarrollo sostenible de la biosfera. Después de los residuos glucosilados, el anillo de benceno es la unidad química estructural más frecuente en la naturaleza, y muchos compuestos aromáticos son contaminantes importantes. Las bacterias han desarrollado estrategias para obtener energía de todo tipo de compuestos mediante procesos aeróbicos o anaeróbicos (utilizando aceptores finales de electrones alternativos como los iones nitrato, sulfato y férrico). Los grupos de genes que intervienen en el catabolismo de compuestos aromáticos suelen localizarse en elementos genéticos móviles, tales como transposones y plásmidos. Dicha localización facilita su transferencia a otros organismos y, por tanto, la rápida adaptación de los microorganismos a nuevos contaminantes. Una estrategia que se ha empleado con éxito en procesos de biorremediación in situ es la combinación, en una única cepa bacteriana o en un consorcio microbiano, de diferentes capacidades degradadoras con otras características genéticas que aporten alguna ventaja selectiva en un ambiente determinado. Los métodos de alto rendimiento de secuenciación de DNAy de análisis global de la expresión génica (genómica) y funcional (proteómica), junto con los avances en los modelos in silico del metabolismo microbiano, proporcionan un enfoque global y racional para conocer las enormes posibilidades, aún inexploradas en su mayor parte, de la utilización de los microorganismos en procesos de biotecnología ambiental que faciliten el desarrollo sostenible.Research in our laboratory is supported by grants 07M/0127/2000 and 07M/0076/2002 from the Comunidad Autónoma de Madrid, grants BIO2000-1076, BIO2003-01482, VEM2003-20075-CO2-02, and GEN2001-4698-CO5-02 from the CICYT, and by the EU contract QLRT-2001-02884.Peer reviewedSociedad Española de Microbiología200720072004info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/2134reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglésinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/21342026-05-22T06:33:51Z
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