Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice
The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice. In colonic mucosa of DIO mice, the MaR1 treatment decreased the expression of inflammator...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/66254 |
| Acceso en línea: | https://hdl.handle.net/10171/66254 |
| Access Level: | acceso abierto |
| Palabra clave: | MaR1 SPMs Dysbiosis Microbiota Colonic mucosa Inflammation |
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Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese MiceLeón, I.C. (Irene C.)|||/items/c38d1aa9-c610-4733-9a3a-0e977ab3cc5bVázquez, S. (Sergio)|||/items/48c94e3d-6fb2-44fa-98d9-1e916d9f710fSainz-Amillo, N. (Neira)|||/items/489b1d3f-6e84-4dfc-8d98-11d6340fd177Guruceaga-Martínez, E. (Elizabeth)|||/items/71d8df8b-4fab-4004-a38e-4057dddc85b2Escoté-Miró, X. (Xavier)|||/items/1058cc70-0041-4df3-b21d-580f6edb6c7cMoreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82MaR1SPMsDysbiosisMicrobiotaColonic mucosaInflammationThe aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice. In colonic mucosa of DIO mice, the MaR1 treatment decreased the expression of inflammatory genes, such as Tnf-α and Il-1β. As expected, the DIO mice exhibited significant changes in gut microbiota composition at the phylum, genus, and species levels, with a trend to a higher Firmicutes/Bacteroidetes ratio. Deferribacteres and Synergistetes also increased in the DIO animals. In contrast, these animals exhibited a significant decrease in the content of Cyanobacteria and Actinobacteria. Treatment with MaR1 was not able to reverse the dysbiosis caused by obesity on the most abundant phyla. However, the MaR1 treatment increased the content of P. xylanivorans, which have been considered to be a promising probiotic with healthy effects on gut inflammation. Finally, a positive association was found between the Deferribacteres and Il-1β expression, suggesting that the increase in Deferribacteres observed in obesity could contribute to the overexpression of inflammatory cytokines in the colonic mucosa. In conclusion, MaR1 administration ameliorates the inflammatory state in the colonic mucosa and partially compensates changes on gut microbiota caused by obesity.Dadun. Depósito Académico Digital Universidad de Navarra20232023-05-1620202020-01-0120202020-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/66254reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/662542026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| title |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| spellingShingle |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice León, I.C. (Irene C.)|||/items/c38d1aa9-c610-4733-9a3a-0e977ab3cc5b MaR1 SPMs Dysbiosis Microbiota Colonic mucosa Inflammation |
| title_short |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| title_full |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| title_fullStr |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| title_full_unstemmed |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| title_sort |
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice |
| dc.creator.none.fl_str_mv |
León, I.C. (Irene C.)|||/items/c38d1aa9-c610-4733-9a3a-0e977ab3cc5b Vázquez, S. (Sergio)|||/items/48c94e3d-6fb2-44fa-98d9-1e916d9f710f Sainz-Amillo, N. (Neira)|||/items/489b1d3f-6e84-4dfc-8d98-11d6340fd177 Guruceaga-Martínez, E. (Elizabeth)|||/items/71d8df8b-4fab-4004-a38e-4057dddc85b2 Escoté-Miró, X. (Xavier)|||/items/1058cc70-0041-4df3-b21d-580f6edb6c7c Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 |
| author |
León, I.C. (Irene C.)|||/items/c38d1aa9-c610-4733-9a3a-0e977ab3cc5b |
| author_facet |
León, I.C. (Irene C.)|||/items/c38d1aa9-c610-4733-9a3a-0e977ab3cc5b Vázquez, S. (Sergio)|||/items/48c94e3d-6fb2-44fa-98d9-1e916d9f710f Sainz-Amillo, N. (Neira)|||/items/489b1d3f-6e84-4dfc-8d98-11d6340fd177 Guruceaga-Martínez, E. (Elizabeth)|||/items/71d8df8b-4fab-4004-a38e-4057dddc85b2 Escoté-Miró, X. (Xavier)|||/items/1058cc70-0041-4df3-b21d-580f6edb6c7c Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 |
| author_role |
author |
| author2 |
Vázquez, S. (Sergio)|||/items/48c94e3d-6fb2-44fa-98d9-1e916d9f710f Sainz-Amillo, N. (Neira)|||/items/489b1d3f-6e84-4dfc-8d98-11d6340fd177 Guruceaga-Martínez, E. (Elizabeth)|||/items/71d8df8b-4fab-4004-a38e-4057dddc85b2 Escoté-Miró, X. (Xavier)|||/items/1058cc70-0041-4df3-b21d-580f6edb6c7c Moreno-Aliaga, M. J. (María Jesús)|||/items/79b762db-92f6-43e2-ba5a-d94e1a69aa82 |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
MaR1 SPMs Dysbiosis Microbiota Colonic mucosa Inflammation |
| topic |
MaR1 SPMs Dysbiosis Microbiota Colonic mucosa Inflammation |
| description |
The aim of this study was to characterize the effects of Maresin 1 (MaR1), a DHA-derived pro-resolving lipid mediator, on obesity-related colonic inflammation and gut dysbiosis in diet-induced obese (DIO) mice. In colonic mucosa of DIO mice, the MaR1 treatment decreased the expression of inflammatory genes, such as Tnf-α and Il-1β. As expected, the DIO mice exhibited significant changes in gut microbiota composition at the phylum, genus, and species levels, with a trend to a higher Firmicutes/Bacteroidetes ratio. Deferribacteres and Synergistetes also increased in the DIO animals. In contrast, these animals exhibited a significant decrease in the content of Cyanobacteria and Actinobacteria. Treatment with MaR1 was not able to reverse the dysbiosis caused by obesity on the most abundant phyla. However, the MaR1 treatment increased the content of P. xylanivorans, which have been considered to be a promising probiotic with healthy effects on gut inflammation. Finally, a positive association was found between the Deferribacteres and Il-1β expression, suggesting that the increase in Deferribacteres observed in obesity could contribute to the overexpression of inflammatory cytokines in the colonic mucosa. In conclusion, MaR1 administration ameliorates the inflammatory state in the colonic mucosa and partially compensates changes on gut microbiota caused by obesity. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-01-01 2020 2020-01-01 2023 2023-05-16 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/66254 |
| url |
https://hdl.handle.net/10171/66254 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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