Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface

Titanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two antibacterial agents (silver nanoparticles and...

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Autores: Moreno Duarte, Daniel, Buxadera Palomero, Judit|||0000-0003-0897-2093, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Manero Planella, José María|||0000-0002-1673-4389, Martín Gómez, Helena|||0000-0001-8956-116X, Mas Moruno, Carlos|||0000-0001-8337-0872, Rodríguez Rius, Daniel|||0000-0001-6286-5200
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/393223
Acceso en línea:https://hdl.handle.net/2117/393223
https://dx.doi.org/10.3390/ijms24119739
Access Level:acceso abierto
Palabra clave:Implants, Artificial
Titanium
Titanium functionalization
Silver nanoparticles
Antimicrobial peptide
Staphylococcus aureus
Silanization
Implants artificials
Titani
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Implants artificials
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network_acronym_str ES
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repository_id_str
spelling Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surfaceMoreno Duarte, DanielBuxadera Palomero, Judit|||0000-0003-0897-2093Ginebra Molins, Maria Pau|||0000-0002-4700-5621Manero Planella, José María|||0000-0002-1673-4389Martín Gómez, Helena|||0000-0001-8956-116XMas Moruno, Carlos|||0000-0001-8337-0872Rodríguez Rius, Daniel|||0000-0001-6286-5200Implants, ArtificialTitaniumTitanium functionalizationSilver nanoparticlesAntimicrobial peptideStaphylococcus aureusSilanizationImplants artificialsTitaniÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Implants artificialsTitanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two antibacterial agents (silver nanoparticles and a multifunctional antimicrobial peptide) were used to coat titanium surfaces. The modulation of the nanoparticle (˜32.1 ± 9.4 nm) density on titanium could be optimized, and a sequential functionalization with both agents was achieved through a two-step functionalization method by means of surface silanization. The antibacterial character of the coating agents was assessed individually as well as combined. The results have shown that a reduction in bacteria after 4 h of incubation can be achieved on all the coated surfaces. After 24 h of incubation, however, the individual antimicrobial peptide coating was more effective than the silver nanoparticles or their combination against Staphylococcus aureus. All tested coatings were non-cytotoxic for eukaryotic cells.Peer ReviewedMultidisciplinary Digital Publishing Institute (MDPI)20232023-06-0420232023-09-07journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/393223https://dx.doi.org/10.3390/ijms24119739reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3932232026-05-27T15:37:01Z
dc.title.none.fl_str_mv Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
title Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
spellingShingle Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
Moreno Duarte, Daniel
Implants, Artificial
Titanium
Titanium functionalization
Silver nanoparticles
Antimicrobial peptide
Staphylococcus aureus
Silanization
Implants artificials
Titani
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Implants artificials
title_short Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
title_full Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
title_fullStr Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
title_full_unstemmed Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
title_sort Comparison of the antibacterial effect of silver nanoparticles and a multifunctional antimicrobial peptide on titanium surface
dc.creator.none.fl_str_mv Moreno Duarte, Daniel
Buxadera Palomero, Judit|||0000-0003-0897-2093
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Martín Gómez, Helena|||0000-0001-8956-116X
Mas Moruno, Carlos|||0000-0001-8337-0872
Rodríguez Rius, Daniel|||0000-0001-6286-5200
author Moreno Duarte, Daniel
author_facet Moreno Duarte, Daniel
Buxadera Palomero, Judit|||0000-0003-0897-2093
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Martín Gómez, Helena|||0000-0001-8956-116X
Mas Moruno, Carlos|||0000-0001-8337-0872
Rodríguez Rius, Daniel|||0000-0001-6286-5200
author_role author
author2 Buxadera Palomero, Judit|||0000-0003-0897-2093
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Manero Planella, José María|||0000-0002-1673-4389
Martín Gómez, Helena|||0000-0001-8956-116X
Mas Moruno, Carlos|||0000-0001-8337-0872
Rodríguez Rius, Daniel|||0000-0001-6286-5200
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Implants, Artificial
Titanium
Titanium functionalization
Silver nanoparticles
Antimicrobial peptide
Staphylococcus aureus
Silanization
Implants artificials
Titani
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Implants artificials
topic Implants, Artificial
Titanium
Titanium functionalization
Silver nanoparticles
Antimicrobial peptide
Staphylococcus aureus
Silanization
Implants artificials
Titani
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Implants artificials
description Titanium implantation success may be compromised by Staphylococcus aureus surface colonization and posterior infection. To avoid this issue, different strategies have been investigated to promote an antibacterial character to titanium. In this work, two antibacterial agents (silver nanoparticles and a multifunctional antimicrobial peptide) were used to coat titanium surfaces. The modulation of the nanoparticle (˜32.1 ± 9.4 nm) density on titanium could be optimized, and a sequential functionalization with both agents was achieved through a two-step functionalization method by means of surface silanization. The antibacterial character of the coating agents was assessed individually as well as combined. The results have shown that a reduction in bacteria after 4 h of incubation can be achieved on all the coated surfaces. After 24 h of incubation, however, the individual antimicrobial peptide coating was more effective than the silver nanoparticles or their combination against Staphylococcus aureus. All tested coatings were non-cytotoxic for eukaryotic cells.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-06-04
2023
2023-09-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/393223
https://dx.doi.org/10.3390/ijms24119739
url https://hdl.handle.net/2117/393223
https://dx.doi.org/10.3390/ijms24119739
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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