Advances in Parkinson's Disease

When James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is considered a complex multifactorial disease in which genetic factors, either causative or susceptibil...

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Autores: Del Rey, Natalia López-González, Quiroga-Varela, Ana, Garbayo, Elisa, Carballo-Carbajal, Iria|||0000-0002-4403-8006, Fernández-Santiago, Rubén|||0000-0002-4582-0702, Monje, Mariana H. G., Trigo-Damas, Inés, Blanco-Prieto, María J., Blesa, Javier|||0000-0002-4257-1325
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226293
Acceso en línea:https://ddd.uab.cat/record/226293
https://dx.doi.org/urn:doi:10.3389/fnana.2018.00113
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Genetics
Drug delivery systems
Non-motor symptoms
Focused ultrasound
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spelling Advances in Parkinson's Disease200 Years LaterDel Rey, Natalia López-GonzálezQuiroga-Varela, AnaGarbayo, ElisaCarballo-Carbajal, Iria|||0000-0002-4403-8006Fernández-Santiago, Rubén|||0000-0002-4582-0702Monje, Mariana H. G.Trigo-Damas, InésBlanco-Prieto, María J.Blesa, Javier|||0000-0002-4257-1325Parkinson's diseaseGeneticsDrug delivery systemsNon-motor symptomsFocused ultrasoundWhen James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is considered a complex multifactorial disease in which genetic factors, either causative or susceptibility variants, unknown environmental cues, and the potential interaction of both could ultimately trigger the pathology. Noteworthy advances have been made in different fields from the clinical phenotype to the decoding of some potential neuropathological features, among which are the fields of genetics, drug discovery or biomaterials for drug delivery, which, though recent in origin, have evolved swiftly to become the basis of research into the disease today. In this review, we highlight some of the key advances in the field over the past two centuries and discuss the current challenges focusing on exciting new research developments likely to come in the next few years. Also, the importance of pre-motor symptoms and early diagnosis in the search for more effective therapeutic options is discussed.Universitat Autònoma de Barcelona 22018-01-0120182018-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226293https://dx.doi.org/urn:doi:10.3389/fnana.2018.00113reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-73508-JINopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2262932026-06-06T12:50:31Z
dc.title.none.fl_str_mv Advances in Parkinson's Disease
200 Years Later
title Advances in Parkinson's Disease
spellingShingle Advances in Parkinson's Disease
Del Rey, Natalia López-González
Parkinson's disease
Genetics
Drug delivery systems
Non-motor symptoms
Focused ultrasound
title_short Advances in Parkinson's Disease
title_full Advances in Parkinson's Disease
title_fullStr Advances in Parkinson's Disease
title_full_unstemmed Advances in Parkinson's Disease
title_sort Advances in Parkinson's Disease
dc.creator.none.fl_str_mv Del Rey, Natalia López-González
Quiroga-Varela, Ana
Garbayo, Elisa
Carballo-Carbajal, Iria|||0000-0002-4403-8006
Fernández-Santiago, Rubén|||0000-0002-4582-0702
Monje, Mariana H. G.
Trigo-Damas, Inés
Blanco-Prieto, María J.
Blesa, Javier|||0000-0002-4257-1325
author Del Rey, Natalia López-González
author_facet Del Rey, Natalia López-González
Quiroga-Varela, Ana
Garbayo, Elisa
Carballo-Carbajal, Iria|||0000-0002-4403-8006
Fernández-Santiago, Rubén|||0000-0002-4582-0702
Monje, Mariana H. G.
Trigo-Damas, Inés
Blanco-Prieto, María J.
Blesa, Javier|||0000-0002-4257-1325
author_role author
author2 Quiroga-Varela, Ana
Garbayo, Elisa
Carballo-Carbajal, Iria|||0000-0002-4403-8006
Fernández-Santiago, Rubén|||0000-0002-4582-0702
Monje, Mariana H. G.
Trigo-Damas, Inés
Blanco-Prieto, María J.
Blesa, Javier|||0000-0002-4257-1325
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Parkinson's disease
Genetics
Drug delivery systems
Non-motor symptoms
Focused ultrasound
topic Parkinson's disease
Genetics
Drug delivery systems
Non-motor symptoms
Focused ultrasound
description When James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is considered a complex multifactorial disease in which genetic factors, either causative or susceptibility variants, unknown environmental cues, and the potential interaction of both could ultimately trigger the pathology. Noteworthy advances have been made in different fields from the clinical phenotype to the decoding of some potential neuropathological features, among which are the fields of genetics, drug discovery or biomaterials for drug delivery, which, though recent in origin, have evolved swiftly to become the basis of research into the disease today. In this review, we highlight some of the key advances in the field over the past two centuries and discuss the current challenges focusing on exciting new research developments likely to come in the next few years. Also, the importance of pre-motor symptoms and early diagnosis in the search for more effective therapeutic options is discussed.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226293
https://dx.doi.org/urn:doi:10.3389/fnana.2018.00113
url https://ddd.uab.cat/record/226293
https://dx.doi.org/urn:doi:10.3389/fnana.2018.00113
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SAF2015-73508-JIN
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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