Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Barradas, Marta; Plaza, Adrián; Colmenarejo, Gonzalo; Lázaro, Iolanda; Costa-Machado, Luis Filipe; Martín-Hernández, Roberto; Micó, Victor; López-Aceituno, José Luis; Herranz, Jesús; Pantoja, Cristina; Tejero, Hector; Diaz-Ruiz, Alberto; Al-Shahrour, Fatima; Daimiel, Lidia; Loria Kohen, Viviana Constanza; Ramírez de Molina, Ana; Efeyan, Alejo; Serrano, Manuel; Pozo, Oscar J.; Sala-Vila, Aleix; Fernández-Marcos, Pablo J.

Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulati...

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Autores:	Barradas, Marta, Plaza, Adrián, Colmenarejo, Gonzalo, Lázaro, Iolanda, Costa-Machado, Luis Filipe, Martín-Hernández, Roberto, Micó, Victor, López-Aceituno, José Luis, Herranz, Jesús, Pantoja, Cristina, Tejero, Hector, Diaz-Ruiz, Alberto, Al-Shahrour, Fatima, Daimiel, Lidia, Loria Kohen, Viviana Constanza, Ramírez de Molina, Ana, Efeyan, Alejo, Serrano, Manuel, Pozo, Oscar J., Sala-Vila, Aleix, Fernández-Marcos, Pablo J.
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Universidad Complutense de Madrid (UCM)
Repositorio:	Docta Complutense
Idioma:	inglés
OAI Identifier:	oai:docta.ucm.es:20.500.14352/104101
Acceso en línea:	https://hdl.handle.net/20.500.14352/104101
Access Level:	acceso abierto
Palabra clave:	612.39 Biología Medicina Dietética y nutrición (Farmacia) 2410 Biología Humana 2499 Otras Especialidades Biológicas

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spelling	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicityBarradas, MartaPlaza, AdriánColmenarejo, GonzaloLázaro, IolandaCosta-Machado, Luis FilipeMartín-Hernández, RobertoMicó, VictorLópez-Aceituno, José LuisHerranz, JesúsPantoja, CristinaTejero, HectorDiaz-Ruiz, AlbertoAl-Shahrour, FatimaDaimiel, LidiaLoria Kohen, Viviana ConstanzaRamírez de Molina, AnaEfeyan, AlejoSerrano, ManuelPozo, Oscar J.Sala-Vila, AleixFernández-Marcos, Pablo J.612.39BiologíaMedicinaDietética y nutrición (Farmacia)2410 Biología Humana2499 Otras Especialidades BiológicasFasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.Nature PortfolioSpringer Science and Business Media LLCUniversidad Complutense de Madrid20222022-09-2720222022-09-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/104101reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1041012026-06-02T12:44:21Z
dc.title.none.fl_str_mv	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
title	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
spellingShingle	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity Barradas, Marta 612.39 Biología Medicina Dietética y nutrición (Farmacia) 2410 Biología Humana 2499 Otras Especialidades Biológicas
title_short	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
title_full	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
title_fullStr	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
title_full_unstemmed	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
title_sort	Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity
dc.creator.none.fl_str_mv	Barradas, Marta Plaza, Adrián Colmenarejo, Gonzalo Lázaro, Iolanda Costa-Machado, Luis Filipe Martín-Hernández, Roberto Micó, Victor López-Aceituno, José Luis Herranz, Jesús Pantoja, Cristina Tejero, Hector Diaz-Ruiz, Alberto Al-Shahrour, Fatima Daimiel, Lidia Loria Kohen, Viviana Constanza Ramírez de Molina, Ana Efeyan, Alejo Serrano, Manuel Pozo, Oscar J. Sala-Vila, Aleix Fernández-Marcos, Pablo J.
author	Barradas, Marta
author_facet	Barradas, Marta Plaza, Adrián Colmenarejo, Gonzalo Lázaro, Iolanda Costa-Machado, Luis Filipe Martín-Hernández, Roberto Micó, Victor López-Aceituno, José Luis Herranz, Jesús Pantoja, Cristina Tejero, Hector Diaz-Ruiz, Alberto Al-Shahrour, Fatima Daimiel, Lidia Loria Kohen, Viviana Constanza Ramírez de Molina, Ana Efeyan, Alejo Serrano, Manuel Pozo, Oscar J. Sala-Vila, Aleix Fernández-Marcos, Pablo J.
author_role	author
author2	Plaza, Adrián Colmenarejo, Gonzalo Lázaro, Iolanda Costa-Machado, Luis Filipe Martín-Hernández, Roberto Micó, Victor López-Aceituno, José Luis Herranz, Jesús Pantoja, Cristina Tejero, Hector Diaz-Ruiz, Alberto Al-Shahrour, Fatima Daimiel, Lidia Loria Kohen, Viviana Constanza Ramírez de Molina, Ana Efeyan, Alejo Serrano, Manuel Pozo, Oscar J. Sala-Vila, Aleix Fernández-Marcos, Pablo J.
author2_role	author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Springer Science and Business Media LLC Universidad Complutense de Madrid
dc.subject.none.fl_str_mv	612.39 Biología Medicina Dietética y nutrición (Farmacia) 2410 Biología Humana 2499 Otras Especialidades Biológicas
topic	612.39 Biología Medicina Dietética y nutrición (Farmacia) 2410 Biología Humana 2499 Otras Especialidades Biológicas
description	Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.
publishDate	2022
dc.date.none.fl_str_mv	2022 2022-09-27 2022 2022-09-27
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.14352/104101
url	https://hdl.handle.net/20.500.14352/104101
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Nature Portfolio
publisher.none.fl_str_mv	Nature Portfolio
dc.source.none.fl_str_mv	reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM)
instname_str	Universidad Complutense de Madrid (UCM)
reponame_str	Docta Complutense
collection	Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,300724

Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

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