Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulati...

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Detalhes bibliográficos
Autores: Barradas, Marta, Plaza, Adrián, Colmenarejo, Gonzalo, Lázaro, Iolanda, Costa-Machado, Luis Filipe, Martín-Hernández, Roberto, Micó, Victor, López-Aceituno, José Luis, Herranz, Jesús, Pantoja, Cristina, Tejero, Hector, Diaz-Ruiz, Alberto, Al-Shahrour, Fatima, Daimiel, Lidia, Loria Kohen, Viviana Constanza, Ramírez de Molina, Ana, Efeyan, Alejo, Serrano, Manuel, Pozo, Oscar J., Sala-Vila, Aleix, Fernández-Marcos, Pablo J.
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/104101
Acesso em linha:https://hdl.handle.net/20.500.14352/104101
Access Level:Acceso aberto
Palavra-chave:612.39
Biología
Medicina
Dietética y nutrición (Farmacia)
2410 Biología Humana
2499 Otras Especialidades Biológicas
Descrição
Resumo:Fasting exerts beneficial effects in mice and humans, including protection from chemotherapy toxicity. To explore the involved mechanisms, we collect blood from humans and mice before and after 36 or 24 hours of fasting, respectively, and measure lipid composition of erythrocyte membranes, circulating micro RNAs (miRNAs), and RNA expression at peripheral blood mononuclear cells (PBMCs). Fasting coordinately affects the proportion of polyunsaturated versus saturated and monounsaturated fatty acids at the erythrocyte membrane; and reduces the expression of insulin signaling-related genes in PBMCs. When fasted for 24 hours before and 24 hours after administration of oxaliplatin or doxorubicin, mice show a strong protection from toxicity in several tissues. Erythrocyte membrane lipids and PBMC gene expression define two separate groups of individuals that accurately predict a differential protection from chemotherapy toxicity, with important clinical implications. Our results reveal a mechanism of fasting associated with lipid homeostasis, and provide biomarkers of fasting to predict fasting-mediated protection from chemotherapy toxicity.

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