Rapid evolution and biogeographic spread in a colorectal cancer
How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic co...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Servizo Galego de Saúde (SERGAS) |
| Repositorio: | RUNA. Repositorio da Consellería de Sanidade e Sergas |
| OAI Identifier: | oai:runa.sergas.gal:20.500.11940/15368 |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pubmed/31723138 http://hdl.handle.net/20.500.11940/15368 |
| Access Level: | acceso abierto |
| Palabra clave: | Humans Genetic Heterogeneity Neoplasm Metastasis Disease Progression Colorectal Neoplasms heterogeneidad genética metástasis neoplásica humanos progresión de la enfermedad neoplasias colorrectales CHUS |
| Sumario: | How and when tumoral clones start spreading to surrounding and distant tissues is currently unclear. Here we leveraged a model-based evolutionary framework to investigate the demographic and biogeographic history of a colorectal cancer. Our analyses strongly support an early monoclonal metastatic colonization, followed by a rapid population expansion at both primary and secondary sites. Moreover, we infer a hematogenous metastatic spread under positive selection, plus the return of some tumoral cells from the liver back to the colon lymph nodes. This study illustrates how sophisticated techniques typical of organismal evolution can provide a detailed, quantitative picture of the complex tumoral dynamics over time and space. |
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