Piperaquine Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers of Papua New Guinea after Administration of Three-Monthly Doses of Dihydroartemisinin–Piperaquine

Mass drug administration (MDA) with monthly dihydroartemisinin-piperaquine (DHA-PQP) appears useful in malaria control and elimination strategies. Determining the relationship between consecutive piperaquine phosphate (PQP) exposure and its impact on QT interval prolongation is a key safety consider...

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Bibliographic Details
Authors: Millat Martínez, Pere, Salman, Sam, Moore, Brioni R., Baró Sastre, Bàrbara, Page-Sharp, Madhu, Batty, Kevin T., Robinson, Leanne J., Pomat, William, Karunajeewa, Harin, Laman, Moses, Manning, Laurens, Mitjà Villar, Oriol, Bassat Orellana, Quique
Format: article
Publication Date:2022
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/202127
Online Access:https://hdl.handle.net/2445/202127
Access Level:Open access
Keyword:Malària
Farmacocinètica
Papua Nova Guinea
Malaria
Pharmacokinetics
Papua New Guinea
Description
Summary:Mass drug administration (MDA) with monthly dihydroartemisinin-piperaquine (DHA-PQP) appears useful in malaria control and elimination strategies. Determining the relationship between consecutive piperaquine phosphate (PQP) exposure and its impact on QT interval prolongation is a key safety consideration for MDA campaigns.

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