Piperaquine Pharmacokinetic and Pharmacodynamic Profiles in Healthy Volunteers of Papua New Guinea after Administration of Three-Monthly Doses of Dihydroartemisinin–Piperaquine

Mass drug administration (MDA) with monthly dihydroartemisinin-piperaquine (DHA-PQP) appears useful in malaria control and elimination strategies. Determining the relationship between consecutive piperaquine phosphate (PQP) exposure and its impact on QT interval prolongation is a key safety consider...

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Detalhes bibliográficos
Autores: Millat Martínez, Pere, Salman, Sam, Moore, Brioni R., Baró Sastre, Bàrbara, Page-Sharp, Madhu, Batty, Kevin T., Robinson, Leanne J., Pomat, William, Karunajeewa, Harin, Laman, Moses, Manning, Laurens, Mitjà Villar, Oriol, Bassat Orellana, Quique
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/202127
Acesso em linha:https://hdl.handle.net/2445/202127
Access Level:acceso abierto
Palavra-chave:Malària
Farmacocinètica
Papua Nova Guinea
Malaria
Pharmacokinetics
Papua New Guinea
Descrição
Resumo:Mass drug administration (MDA) with monthly dihydroartemisinin-piperaquine (DHA-PQP) appears useful in malaria control and elimination strategies. Determining the relationship between consecutive piperaquine phosphate (PQP) exposure and its impact on QT interval prolongation is a key safety consideration for MDA campaigns.

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