Guidelines and definitions for research on epithelial–mesenchymal transition

Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a cons...

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Autores: Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L., Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J., Hadjantonakis, Anna Katerina, Huang, Ruby J.Y., Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D., Mani, Sendurai A., Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E., Newgreen, Donald F., Nieto, M. Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P., Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W., Weinberg, Robert A., Williams, Elizabeth D., Xing, Jianhua, Zhou, Binhua P., Sheng, Guojun
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/693394
Acesso em linha:http://hdl.handle.net/10486/693394
https://dx.doi.org/10.1038/s41580-020-0237-9
Access Level:acceso abierto
Palavra-chave:Epithelial–mesenchymal transition (EMT)
Cellular organization
Consensus statement
Diversity in experimental
Nomenclature
Definitions
Guidelines
Medicina
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spelling Guidelines and definitions for research on epithelial–mesenchymal transitionYang, JingAntin, ParkerBerx, GeertBlanpain, CédricBrabletz, ThomasBronner, MarianneCampbell, KyraCano, AmparoCasanova, JordiChristofori, GerhardDedhar, ShoukatDerynck, RikFord, Heide L.Fuxe, JonasGarcía de Herreros, AntonioGoodall, Gregory J.Hadjantonakis, Anna KaterinaHuang, Ruby J.Y.Kalcheim, ChayaKalluri, RaghuKang, YibinKhew-Goodall, YeesimLevine, HerbertLiu, JinsongLongmore, Gregory D.Mani, Sendurai A.Massagué, JoanMayor, RobertoMcClay, DavidMostov, Keith E.Newgreen, Donald F.Nieto, M. AngelaPuisieux, AlainRunyan, RaymondSavagner, PierreStanger, BenStemmler, Marc P.Takahashi, YoshikoTakeichi, MasatoshiTheveneau, EricThiery, Jean PaulThompson, Erik W.Weinberg, Robert A.Williams, Elizabeth D.Xing, JianhuaZhou, Binhua P.Sheng, GuojunEpithelial–mesenchymal transition (EMT)Cellular organizationConsensus statementDiversity in experimentalNomenclatureDefinitionsGuidelinesMedicinaEpithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.Nature ResearchDepartamento de BioquímicaFacultad de MedicinaInstituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)20202020-06-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/693394https://dx.doi.org/10.1038/s41580-020-0237-9reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6933942026-06-23T12:46:27Z
dc.title.none.fl_str_mv Guidelines and definitions for research on epithelial–mesenchymal transition
title Guidelines and definitions for research on epithelial–mesenchymal transition
spellingShingle Guidelines and definitions for research on epithelial–mesenchymal transition
Yang, Jing
Epithelial–mesenchymal transition (EMT)
Cellular organization
Consensus statement
Diversity in experimental
Nomenclature
Definitions
Guidelines
Medicina
title_short Guidelines and definitions for research on epithelial–mesenchymal transition
title_full Guidelines and definitions for research on epithelial–mesenchymal transition
title_fullStr Guidelines and definitions for research on epithelial–mesenchymal transition
title_full_unstemmed Guidelines and definitions for research on epithelial–mesenchymal transition
title_sort Guidelines and definitions for research on epithelial–mesenchymal transition
dc.creator.none.fl_str_mv Yang, Jing
Antin, Parker
Berx, Geert
Blanpain, Cédric
Brabletz, Thomas
Bronner, Marianne
Campbell, Kyra
Cano, Amparo
Casanova, Jordi
Christofori, Gerhard
Dedhar, Shoukat
Derynck, Rik
Ford, Heide L.
Fuxe, Jonas
García de Herreros, Antonio
Goodall, Gregory J.
Hadjantonakis, Anna Katerina
Huang, Ruby J.Y.
Kalcheim, Chaya
Kalluri, Raghu
Kang, Yibin
Khew-Goodall, Yeesim
Levine, Herbert
Liu, Jinsong
Longmore, Gregory D.
Mani, Sendurai A.
Massagué, Joan
Mayor, Roberto
McClay, David
Mostov, Keith E.
Newgreen, Donald F.
Nieto, M. Angela
Puisieux, Alain
Runyan, Raymond
Savagner, Pierre
Stanger, Ben
Stemmler, Marc P.
Takahashi, Yoshiko
Takeichi, Masatoshi
Theveneau, Eric
Thiery, Jean Paul
Thompson, Erik W.
Weinberg, Robert A.
Williams, Elizabeth D.
Xing, Jianhua
Zhou, Binhua P.
Sheng, Guojun
author Yang, Jing
author_facet Yang, Jing
Antin, Parker
Berx, Geert
Blanpain, Cédric
Brabletz, Thomas
Bronner, Marianne
Campbell, Kyra
Cano, Amparo
Casanova, Jordi
Christofori, Gerhard
Dedhar, Shoukat
Derynck, Rik
Ford, Heide L.
Fuxe, Jonas
García de Herreros, Antonio
Goodall, Gregory J.
Hadjantonakis, Anna Katerina
Huang, Ruby J.Y.
Kalcheim, Chaya
Kalluri, Raghu
Kang, Yibin
Khew-Goodall, Yeesim
Levine, Herbert
Liu, Jinsong
Longmore, Gregory D.
Mani, Sendurai A.
Massagué, Joan
Mayor, Roberto
McClay, David
Mostov, Keith E.
Newgreen, Donald F.
Nieto, M. Angela
Puisieux, Alain
Runyan, Raymond
Savagner, Pierre
Stanger, Ben
Stemmler, Marc P.
Takahashi, Yoshiko
Takeichi, Masatoshi
Theveneau, Eric
Thiery, Jean Paul
Thompson, Erik W.
Weinberg, Robert A.
Williams, Elizabeth D.
Xing, Jianhua
Zhou, Binhua P.
Sheng, Guojun
author_role author
author2 Antin, Parker
Berx, Geert
Blanpain, Cédric
Brabletz, Thomas
Bronner, Marianne
Campbell, Kyra
Cano, Amparo
Casanova, Jordi
Christofori, Gerhard
Dedhar, Shoukat
Derynck, Rik
Ford, Heide L.
Fuxe, Jonas
García de Herreros, Antonio
Goodall, Gregory J.
Hadjantonakis, Anna Katerina
Huang, Ruby J.Y.
Kalcheim, Chaya
Kalluri, Raghu
Kang, Yibin
Khew-Goodall, Yeesim
Levine, Herbert
Liu, Jinsong
Longmore, Gregory D.
Mani, Sendurai A.
Massagué, Joan
Mayor, Roberto
McClay, David
Mostov, Keith E.
Newgreen, Donald F.
Nieto, M. Angela
Puisieux, Alain
Runyan, Raymond
Savagner, Pierre
Stanger, Ben
Stemmler, Marc P.
Takahashi, Yoshiko
Takeichi, Masatoshi
Theveneau, Eric
Thiery, Jean Paul
Thompson, Erik W.
Weinberg, Robert A.
Williams, Elizabeth D.
Xing, Jianhua
Zhou, Binhua P.
Sheng, Guojun
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Bioquímica
Facultad de Medicina
Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM)
dc.subject.none.fl_str_mv Epithelial–mesenchymal transition (EMT)
Cellular organization
Consensus statement
Diversity in experimental
Nomenclature
Definitions
Guidelines
Medicina
topic Epithelial–mesenchymal transition (EMT)
Cellular organization
Consensus statement
Diversity in experimental
Nomenclature
Definitions
Guidelines
Medicina
description Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-06-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/693394
https://dx.doi.org/10.1038/s41580-020-0237-9
url http://hdl.handle.net/10486/693394
https://dx.doi.org/10.1038/s41580-020-0237-9
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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