In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-tomesenchymal transition

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEM...

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Detalles Bibliográficos
Autores: Mitchel , Jennifer A., Das, Amit, O’Sullivan, Michael J., Stancil, Ian T., DeCamp, Stephen J., Koehler, Stephan, Ocaña , Oscar H., Butler, James P., Fredberg, Jeffrey J., Nieto , M. Angela, Bi, Dapeng, Park, Jin-Ah
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Jaén
Repositorio:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
OAI Identifier:oai:ruja.ujaen.es:10953/7299
Acceso en línea:https://hdl.handle.net/10953/7299
Access Level:acceso abierto
Palabra clave:Unjamming transition
Collective cell migration
Epithelial mechanics
Partial epithelial–mesenchymal transition (pEMT)
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Descripción
Sumario:The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which these core programs are distinct, overlapping, or identical has remained undefined. Here, we triggered partial EMT (pEMT) or UJT in differentiated primary human bronchial epithelial cells. After triggering UJT, cell-cell junctions, apico-basal polarity, and barrier function remain intact, cells elongate and align into cooperative migratory packs, and mesenchymal markers of EMT remain unapparent. After triggering pEMT these and other metrics of UJT versus pEMT diverge. A computational model attributes effects of pEMT mainly to diminished junctional tension but attributes those of UJT mainly to augmented cellular propulsion. Through the actions of UJT and pEMT working independently, sequentially, or interactively, those tissues that are subject to development, injury, or disease become endowed with rich mechanisms for cellular migration, plasticity, self-repair, and regeneration.

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