Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal di...

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Autores: Llorens Domenjó, Elena, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/103940
Acceso en línea:https://hdl.handle.net/2117/103940
https://dx.doi.org/10.1007/s13233-015-3082-5
Access Level:acceso abierto
Palabra clave:Biomedical materials
Electrospinning
Polymers
Bactericides
Polylactic acid
biomaterials
electrospinning
dual drug-release
polylactide
bactericide
triclosan
ketoprofen
poly(lactic acid)
packaging materials
release
nanofibers
poly(l-lactide)
behavior
fibers
crystallization
nanoparticles
Materials biomèdics
Polímers
Àcid polilàctic
Àrees temàtiques de la UPC::Enginyeria química
id ES_f2d406d23b7ddc621484df36b7445672
oai_identifier_str oai:upcommons.upc.edu:2117/103940
network_acronym_str ES
network_name_str España
repository_id_str
spelling Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugsLlorens Domenjó, ElenaValle Mendoza, Luis Javier del|||0000-0001-9916-1741Puiggalí Bellalta, Jordi|||0000-0002-0640-4474Biomedical materialsElectrospinningPolymersBactericidesPolylactic acidbiomaterialselectrospinningdual drug-releasepolylactidebactericidetriclosanketoprofenpoly(lactic acid)packaging materialsreleasenanofiberstriclosanpoly(l-lactide)behaviorfiberscrystallizationnanoparticlesMaterials biomèdicsPolímersBactericidesÀcid polilàcticÀrees temàtiques de la UPC::Enginyeria químicaPolylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.Peer Reviewed20152015-07-0120172017-05-03journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/103940https://dx.doi.org/10.1007/s13233-015-3082-5reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1039402026-05-27T15:37:01Z
dc.title.none.fl_str_mv Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
title Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
spellingShingle Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
Llorens Domenjó, Elena
Biomedical materials
Electrospinning
Polymers
Bactericides
Polylactic acid
biomaterials
electrospinning
dual drug-release
polylactide
bactericide
triclosan
ketoprofen
poly(lactic acid)
packaging materials
release
nanofibers
triclosan
poly(l-lactide)
behavior
fibers
crystallization
nanoparticles
Materials biomèdics
Polímers
Bactericides
Àcid polilàctic
Àrees temàtiques de la UPC::Enginyeria química
title_short Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
title_full Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
title_fullStr Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
title_full_unstemmed Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
title_sort Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs
dc.creator.none.fl_str_mv Llorens Domenjó, Elena
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author Llorens Domenjó, Elena
author_facet Llorens Domenjó, Elena
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author_role author
author2 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author2_role author
author
dc.subject.none.fl_str_mv Biomedical materials
Electrospinning
Polymers
Bactericides
Polylactic acid
biomaterials
electrospinning
dual drug-release
polylactide
bactericide
triclosan
ketoprofen
poly(lactic acid)
packaging materials
release
nanofibers
triclosan
poly(l-lactide)
behavior
fibers
crystallization
nanoparticles
Materials biomèdics
Polímers
Bactericides
Àcid polilàctic
Àrees temàtiques de la UPC::Enginyeria química
topic Biomedical materials
Electrospinning
Polymers
Bactericides
Polylactic acid
biomaterials
electrospinning
dual drug-release
polylactide
bactericide
triclosan
ketoprofen
poly(lactic acid)
packaging materials
release
nanofibers
triclosan
poly(l-lactide)
behavior
fibers
crystallization
nanoparticles
Materials biomèdics
Polímers
Bactericides
Àcid polilàctic
Àrees temàtiques de la UPC::Enginyeria química
description Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-07-01
2017
2017-05-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/103940
https://dx.doi.org/10.1007/s13233-015-3082-5
url https://hdl.handle.net/2117/103940
https://dx.doi.org/10.1007/s13233-015-3082-5
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424318634524672
score 15.301603

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