The polygenic basis of relapse after a first episode of schizophrenia
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | INCLIVA |
| Repositorio: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p17716 |
| Acceso en línea: | https://incliva.portalinvestigacion.com/publicaciones/17716 |
| Access Level: | acceso abierto |
| Palabra clave: | Schizophrenia Relapse Polygenic risk score Cognition |
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The polygenic basis of relapse after a first episode of schizophreniaSegura, Alex-GonzalezProhens, LluciaGasso, PatriciaRodriguez, NataliaGarcia-Rizo, ClementeMoreno-Izco, LuciaAndreu-Bernabeu, AlvaroZorrilla, InakiMane, AnnaRodriguez-Jimenez, RobertoRoldan, AlexandraSarro, SalvadorIbanez, AngelaUsall, JudithSaiz, Pilar ACuesta, Manuel JParellada, MaraGonzalez-Pinto, AnaBerrocoso, EsterBernardo, MiquelMas, SergiMezquida, GiselaArbelo, NestorDe Matteis, MarioGalvan, JoaquinDuque Guerra, AlejandraArias I Queralt, LaiaPerez-Bacigalupe, MariaGonzalez-Ortega, ItxasoToll, AlbaCasanovas, FrancescSanchez-Pastor, LuisValtuena, MercedesPomarol-Clotet, EdithGarcia-Leon, Maria AngelesButjosa, AnaRubio-Abadal, ElenaRibeiro, MariaLopez-Ilundain, Jose MSaiz-Ruiz, JeronimoLeon-Quismondo, LuisRivero, OlgaRuiz, PedroEchevarria, Rafael SegarraGarcia-Portilla, M PazSchizophreniaRelapsePolygenic risk scoreCognitionLittle is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRSEA, showed both a lower risk (OR = 0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96 +/- 1.74 vs. 23.12 +/- 1.14 months, p = 0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse. (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )ELSEVIER2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17716EUROPEAN NEUROPSYCHOPHARMACOLOGYISSN: 0924977XISSNe: 18737862reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p177162026-06-07T16:35:31Z |
| dc.title.none.fl_str_mv |
The polygenic basis of relapse after a first episode of schizophrenia |
| title |
The polygenic basis of relapse after a first episode of schizophrenia |
| spellingShingle |
The polygenic basis of relapse after a first episode of schizophrenia Segura, Alex-Gonzalez Schizophrenia Relapse Polygenic risk score Cognition |
| title_short |
The polygenic basis of relapse after a first episode of schizophrenia |
| title_full |
The polygenic basis of relapse after a first episode of schizophrenia |
| title_fullStr |
The polygenic basis of relapse after a first episode of schizophrenia |
| title_full_unstemmed |
The polygenic basis of relapse after a first episode of schizophrenia |
| title_sort |
The polygenic basis of relapse after a first episode of schizophrenia |
| dc.creator.none.fl_str_mv |
Segura, Alex-Gonzalez Prohens, Llucia Gasso, Patricia Rodriguez, Natalia Garcia-Rizo, Clemente Moreno-Izco, Lucia Andreu-Bernabeu, Alvaro Zorrilla, Inaki Mane, Anna Rodriguez-Jimenez, Roberto Roldan, Alexandra Sarro, Salvador Ibanez, Angela Usall, Judith Saiz, Pilar A Cuesta, Manuel J Parellada, Mara Gonzalez-Pinto, Ana Berrocoso, Ester Bernardo, Miquel Mas, Sergi Mezquida, Gisela Arbelo, Nestor De Matteis, Mario Galvan, Joaquin Duque Guerra, Alejandra Arias I Queralt, Laia Perez-Bacigalupe, Maria Gonzalez-Ortega, Itxaso Toll, Alba Casanovas, Francesc Sanchez-Pastor, Luis Valtuena, Mercedes Pomarol-Clotet, Edith Garcia-Leon, Maria Angeles Butjosa, Ana Rubio-Abadal, Elena Ribeiro, Maria Lopez-Ilundain, Jose M Saiz-Ruiz, Jeronimo Leon-Quismondo, Luis Rivero, Olga Ruiz, Pedro Echevarria, Rafael Segarra Garcia-Portilla, M Paz |
| author |
Segura, Alex-Gonzalez |
| author_facet |
Segura, Alex-Gonzalez Prohens, Llucia Gasso, Patricia Rodriguez, Natalia Garcia-Rizo, Clemente Moreno-Izco, Lucia Andreu-Bernabeu, Alvaro Zorrilla, Inaki Mane, Anna Rodriguez-Jimenez, Roberto Roldan, Alexandra Sarro, Salvador Ibanez, Angela Usall, Judith Saiz, Pilar A Cuesta, Manuel J Parellada, Mara Gonzalez-Pinto, Ana Berrocoso, Ester Bernardo, Miquel Mas, Sergi Mezquida, Gisela Arbelo, Nestor De Matteis, Mario Galvan, Joaquin Duque Guerra, Alejandra Arias I Queralt, Laia Perez-Bacigalupe, Maria Gonzalez-Ortega, Itxaso Toll, Alba Casanovas, Francesc Sanchez-Pastor, Luis Valtuena, Mercedes Pomarol-Clotet, Edith Garcia-Leon, Maria Angeles Butjosa, Ana Rubio-Abadal, Elena Ribeiro, Maria Lopez-Ilundain, Jose M Saiz-Ruiz, Jeronimo Leon-Quismondo, Luis Rivero, Olga Ruiz, Pedro Echevarria, Rafael Segarra Garcia-Portilla, M Paz |
| author_role |
author |
| author2 |
Prohens, Llucia Gasso, Patricia Rodriguez, Natalia Garcia-Rizo, Clemente Moreno-Izco, Lucia Andreu-Bernabeu, Alvaro Zorrilla, Inaki Mane, Anna Rodriguez-Jimenez, Roberto Roldan, Alexandra Sarro, Salvador Ibanez, Angela Usall, Judith Saiz, Pilar A Cuesta, Manuel J Parellada, Mara Gonzalez-Pinto, Ana Berrocoso, Ester Bernardo, Miquel Mas, Sergi Mezquida, Gisela Arbelo, Nestor De Matteis, Mario Galvan, Joaquin Duque Guerra, Alejandra Arias I Queralt, Laia Perez-Bacigalupe, Maria Gonzalez-Ortega, Itxaso Toll, Alba Casanovas, Francesc Sanchez-Pastor, Luis Valtuena, Mercedes Pomarol-Clotet, Edith Garcia-Leon, Maria Angeles Butjosa, Ana Rubio-Abadal, Elena Ribeiro, Maria Lopez-Ilundain, Jose M Saiz-Ruiz, Jeronimo Leon-Quismondo, Luis Rivero, Olga Ruiz, Pedro Echevarria, Rafael Segarra Garcia-Portilla, M Paz |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Schizophrenia Relapse Polygenic risk score Cognition |
| topic |
Schizophrenia Relapse Polygenic risk score Cognition |
| description |
Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRSEA, showed both a lower risk (OR = 0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96 +/- 1.74 vs. 23.12 +/- 1.14 months, p = 0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse. (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://incliva.portalinvestigacion.com/publicaciones/17716 |
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https://incliva.portalinvestigacion.com/publicaciones/17716 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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ELSEVIER |
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ELSEVIER |
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EUROPEAN NEUROPSYCHOPHARMACOLOGY ISSN: 0924977X ISSNe: 18737862 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA |
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INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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15,81155 |