The polygenic basis of relapse after a first episode of schizophrenia

Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major...

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Autores: Segura, Alex-Gonzalez, Prohens, Llucia, Gasso, Patricia, Rodriguez, Natalia, Garcia-Rizo, Clemente, Moreno-Izco, Lucia, Andreu-Bernabeu, Alvaro, Zorrilla, Inaki, Mane, Anna, Rodriguez-Jimenez, Roberto, Roldan, Alexandra, Sarro, Salvador, Ibanez, Angela, Usall, Judith, Saiz, Pilar A, Cuesta, Manuel J, Parellada, Mara, Gonzalez-Pinto, Ana, Berrocoso, Ester, Bernardo, Miquel, Mas, Sergi, Mezquida, Gisela, Arbelo, Nestor, De Matteis, Mario, Galvan, Joaquin, Duque Guerra, Alejandra, Arias I Queralt, Laia, Perez-Bacigalupe, Maria, Gonzalez-Ortega, Itxaso, Toll, Alba, Casanovas, Francesc, Sanchez-Pastor, Luis, Valtuena, Mercedes, Pomarol-Clotet, Edith, Garcia-Leon, Maria Angeles, Butjosa, Ana, Rubio-Abadal, Elena, Ribeiro, Maria, Lopez-Ilundain, Jose M, Saiz-Ruiz, Jeronimo, Leon-Quismondo, Luis, Rivero, Olga, Ruiz, Pedro, Echevarria, Rafael Segarra, Garcia-Portilla, M Paz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17716
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17716
Access Level:acceso abierto
Palabra clave:Schizophrenia
Relapse
Polygenic risk score
Cognition
Descripción
Sumario:Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRSEA, showed both a lower risk (OR = 0.29, 95% CI [0.11-0.73]) and a later onset of relapse (30.96 +/- 1.74 vs. 23.12 +/- 1.14 months, p = 0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse. (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

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