The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI

The SIMGI (SIMulator Gastro-Intestinal) is an automated gastrointestinal in vitro model designed to dynamically simulate the physiological processes taking place during digestion in the stomach and small intestine, as well as to reproduce the colonic microbiota responsible for metabolic bioconversio...

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Detalles Bibliográficos
Autores: Barroso, Elvira, Cueva, Carolina, Peláez, Carmen, Martínez-Cuesta, M. Carmen, Requena, Teresa
Tipo de recurso: otro
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/151895
Acceso en línea:http://hdl.handle.net/10261/151895
Access Level:acceso abierto
Palabra clave:Three-stage fermentation
SIMGI
Automated in vitro dynamic model
Colon microbiota
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spelling The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGIBarroso, ElviraCueva, CarolinaPeláez, CarmenMartínez-Cuesta, M. CarmenRequena, TeresaThree-stage fermentationSIMGIAutomated in vitro dynamic modelColon microbiotaThe SIMGI (SIMulator Gastro-Intestinal) is an automated gastrointestinal in vitro model designed to dynamically simulate the physiological processes taking place during digestion in the stomach and small intestine, as well as to reproduce the colonic microbiota responsible for metabolic bioconversions in the large intestine. This computer-controlled system is a flexible modulating system that combines a gastric compartment that operates with peristaltic mixing movements, a reactor simulating the small intestine and three-stage continuous reactors that reproduce the colon region-specific microbiota. The compartments designed for digestion (stomach and small intestine) and fermentation (colon) can be connected to operate jointly. Alternatively, the digestion and fermentation processes can proceed independently. This section describes the conditions needed to inoculate, stabilize and differentiate the fecal microbiota in the SIMGI system, as well as the steps to follow in order to test the stabilized colonic microbiota with different food ingredients and/or by modifying the caloric intake in the nutrition media.Open Access: This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License.Peer ReviewedSpringer NatureConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2017201720152017info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Publisher's versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/151895reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1007/978-3-319-16104-4_28Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1518952026-05-22T06:33:51Z
dc.title.none.fl_str_mv The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
title The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
spellingShingle The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
Barroso, Elvira
Three-stage fermentation
SIMGI
Automated in vitro dynamic model
Colon microbiota
title_short The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
title_full The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
title_fullStr The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
title_full_unstemmed The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
title_sort The computer-controlled multicompartmental dynamic model of the gastrointestinal system SIMGI
dc.creator.none.fl_str_mv Barroso, Elvira
Cueva, Carolina
Peláez, Carmen
Martínez-Cuesta, M. Carmen
Requena, Teresa
author Barroso, Elvira
author_facet Barroso, Elvira
Cueva, Carolina
Peláez, Carmen
Martínez-Cuesta, M. Carmen
Requena, Teresa
author_role author
author2 Cueva, Carolina
Peláez, Carmen
Martínez-Cuesta, M. Carmen
Requena, Teresa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Three-stage fermentation
SIMGI
Automated in vitro dynamic model
Colon microbiota
topic Three-stage fermentation
SIMGI
Automated in vitro dynamic model
Colon microbiota
description The SIMGI (SIMulator Gastro-Intestinal) is an automated gastrointestinal in vitro model designed to dynamically simulate the physiological processes taking place during digestion in the stomach and small intestine, as well as to reproduce the colonic microbiota responsible for metabolic bioconversions in the large intestine. This computer-controlled system is a flexible modulating system that combines a gastric compartment that operates with peristaltic mixing movements, a reactor simulating the small intestine and three-stage continuous reactors that reproduce the colon region-specific microbiota. The compartments designed for digestion (stomach and small intestine) and fermentation (colon) can be connected to operate jointly. Alternatively, the digestion and fermentation processes can proceed independently. This section describes the conditions needed to inoculate, stabilize and differentiate the fecal microbiota in the SIMGI system, as well as the steps to follow in order to test the stabilized colonic microbiota with different food ingredients and/or by modifying the caloric intake in the nutrition media.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Publisher's version
info:eu-repo/semantics/publishedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/151895
url http://hdl.handle.net/10261/151895
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1007/978-3-319-16104-4_28
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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