Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma

This article belongs to the Special Issue Personalized Medicine: Recent Progress in Cancer Therapy.

Detalles Bibliográficos
Autores: Alonso-Álvarez, Sara, Alcoceba, Miguel, García-Alvarez, María, Blanco, Óscar, Rodríguez, Marta, Baile, Mónica, Caballero, Juan Carlos, Dávila, Julio, Vidriales, Maria Belén, Esteban, Carmen, Arias, Piedad, Díaz, Luis G., Tamayo, Pilar, Caballero, Maria Dolores, Gutiérrez, Norma Carmen, González, Marcos, Martín, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/222745
Acceso en línea:http://hdl.handle.net/10261/222745
Access Level:acceso abierto
Palabra clave:Bone marrow involvement
Diffuse large B-cell lymphoma
Discordant bone marrow
Concordant bone marrow
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spelling Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphomaAlonso-Álvarez, SaraAlcoceba, MiguelGarcía-Alvarez, MaríaBlanco, ÓscarRodríguez, MartaBaile, MónicaCaballero, Juan CarlosDávila, JulioVidriales, Maria BelénEsteban, CarmenArias, PiedadDíaz, Luis G.Tamayo, PilarCaballero, Maria DoloresGutiérrez, Norma CarmenGonzález, MarcosMartín, AlejandroBone marrow involvementDiffuse large B-cell lymphomaDiscordant bone marrowConcordant bone marrowThis article belongs to the Special Issue Personalized Medicine: Recent Progress in Cancer Therapy.The biology and clinical impact of bone marrow (BM) infiltration in patients with diffuse large B-cell lymphoma (DLBCL) remains unclear in the rituximab era. We retrospectively analyzed 232 patients diagnosed with DLBCL at our center between 1999 and 2014. Concordant-presence of large cells similar to those of the lymph node biopsy- and discordant-infiltration by small cells forming lymphoid aggregates, lacking cytological atypia-BM infiltration was defined by histological criteria and further characterized by flow cytometry (FCM). Cell of origin (COO) was determined using Hans’ algorithm. For the clonal relationship between tumor and discordant BM, the VDJH rearrangement was analyzed. Survival analyses were restricted to 189 patients treated with rituximab and chemotherapy. Thirty-six (16%) had concordant, and 37 (16%) discordant BM infiltration. FCM described different indolent lymphomas among discordant cases, clonally related with DLBCL in 10/13 available samples. Median follow-up was 58 months. 5-year-progression-free survival (PFS) for non-infiltrated, discordant and concordant groups was 68%, 65% and 30%, respectively (p < 0.001). Combining COO and BM infiltration, patients with discordant BM and non-germinal center B-cell COO also had decreased 5-year-PFS (41.9%). In multivariate analysis, concordant BM had an independent effect on PFS (HR 2.5, p = 0.01). Five-year cumulative incidence of central nervous system (CNS) relapse was 21%, 4% and 1% in concordant, discordant and non-infiltrated groups, respectively (p < 0.001). In conclusion, concordant BM infiltration represents a subset with poor prognosis, whereas the prognostic impact of discordant BM infiltration could be limited to non-CGB cases.This work was partially supported by the Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness PI13/02644, PI15/01393, RD12/0036/0069, CIBERONC-CB16/12/00233, and “Una manera de hacer Europa” (Innocampus; CEI-2010-1-0010)”, the Health Council of the Junta de Castilla y León (GRS 850/A/13, GRS 1180/A/15, GRS 1350/A/16, GRS 1846/A/18, GRS 2035/A/19, and BIO/SA78/15), and Gilead Sciences (GLD17/00334). All Spanish funding is co-sponsored by the European Union FEDER program.Peer reviewedMultidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIIJunta de Castilla y LeónEuropean CommissionGilead SciencesMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/222745reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/cancers12020474Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2227452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
title Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
spellingShingle Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
Alonso-Álvarez, Sara
Bone marrow involvement
Diffuse large B-cell lymphoma
Discordant bone marrow
Concordant bone marrow
title_short Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
title_full Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
title_fullStr Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
title_full_unstemmed Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
title_sort Biological features and prognostic impact of bone marrow infiltration in patients with diffuse large B-cell lymphoma
dc.creator.none.fl_str_mv Alonso-Álvarez, Sara
Alcoceba, Miguel
García-Alvarez, María
Blanco, Óscar
Rodríguez, Marta
Baile, Mónica
Caballero, Juan Carlos
Dávila, Julio
Vidriales, Maria Belén
Esteban, Carmen
Arias, Piedad
Díaz, Luis G.
Tamayo, Pilar
Caballero, Maria Dolores
Gutiérrez, Norma Carmen
González, Marcos
Martín, Alejandro
author Alonso-Álvarez, Sara
author_facet Alonso-Álvarez, Sara
Alcoceba, Miguel
García-Alvarez, María
Blanco, Óscar
Rodríguez, Marta
Baile, Mónica
Caballero, Juan Carlos
Dávila, Julio
Vidriales, Maria Belén
Esteban, Carmen
Arias, Piedad
Díaz, Luis G.
Tamayo, Pilar
Caballero, Maria Dolores
Gutiérrez, Norma Carmen
González, Marcos
Martín, Alejandro
author_role author
author2 Alcoceba, Miguel
García-Alvarez, María
Blanco, Óscar
Rodríguez, Marta
Baile, Mónica
Caballero, Juan Carlos
Dávila, Julio
Vidriales, Maria Belén
Esteban, Carmen
Arias, Piedad
Díaz, Luis G.
Tamayo, Pilar
Caballero, Maria Dolores
Gutiérrez, Norma Carmen
González, Marcos
Martín, Alejandro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Junta de Castilla y León
European Commission
Gilead Sciences
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bone marrow involvement
Diffuse large B-cell lymphoma
Discordant bone marrow
Concordant bone marrow
topic Bone marrow involvement
Diffuse large B-cell lymphoma
Discordant bone marrow
Concordant bone marrow
description This article belongs to the Special Issue Personalized Medicine: Recent Progress in Cancer Therapy.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/222745
url http://hdl.handle.net/10261/222745
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/cancers12020474
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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