Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis

Backgound: In the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component of FLIPI and FLIPI2, the most widely used outcome scores. During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one...

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Detalhes bibliográficos
Autores: Ródenas-Quiñonero, Isabel|||0000-0002-2642-0914, Chen-Liang, Tzu|||0000-0001-5969-8640, Martín Santos, Taida, Salar Silvestre, Antonio|||0000-0002-4652-4825, Fernández-González, Marta|||0000-0001-9949-8504, Celades, Carolina, Navarro Ferrando, José Tomás|||0000-0001-9101-6013, Martínez-Garcia, Ana Belén, Andreu, Rafael|||0000-0002-9220-3352, Balaguer, Aitana|||0000-0003-1633-2918, Martín García-Sancho, Alejandro|||0000-0001-6330-1028, Baile, Mónica, Lopez-Jimenez, Javier|||0000-0002-2969-3002, Marquet-Palomanes, Juan|||0000-0002-8484-1442, Teruel, Ana Isabel|||0000-0003-1559-7607, Terol, Maria Jose|||0000-0002-9467-932X, Benet, Carmen, Frutos, Laura, Navarro, José Luís, Uña-Gorospe, Jon, Suarez, Marina, Cortés, Montserrat A., Contreras, José, Ruiz, Cristina|||0009-0006-0100-382X, Tamayo, Pilar, Mucientes, Jorge|||0000-0002-3107-5326, Sopena-Novales, Pablo, Reguilón-Gallego, Laura, Sánchez-Blanco, José Javier, Pérez-Ceballos, Elena, Jerez, Andrés|||0000-0002-2079-6638, Ortuño, Francisco José|||0000-0003-4450-9346
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289381
Acesso em linha:https://ddd.uab.cat/record/289381
https://dx.doi.org/urn:doi:10.1002/cam4.5424
Access Level:acceso abierto
Palavra-chave:Bone marrow biopsy
Follicular lymphoma
PET/CT
Descrição
Resumo:Backgound: In the workup of follicular lymphoma (FL), bone marrow biopsy (BMB) assessment is a key component of FLIPI and FLIPI2, the most widely used outcome scores. During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques. Methods: The aim of our study was to evaluate the diagnostic accuracy and the prognostic impact of both procedures in a retrospective cohort of 299 FL patients with both tests performed at diagnosis. In order to avoid a collinearity bias, FLIPI2 was deconstructed in its founding parameters, and the bone marrow involvement (BMI) parameter separately included as: a positive BMB, a positive PET/CT, the combined "PET/CT and BMB positive" or "PET/CT or BMB positive". These variables were also confronted independently with the POD24 in 233 patients treated with intensive regimens. Results: In the total cohort, bone marrow was involved in 124 and 60 patients by BMB and PET/CT, respectively. In terms of overall survival, age.

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