The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1

Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence d...

Descripción completa

Detalles Bibliográficos
Autores: Pujol-Carrion, Nuria, Pavón Verges, Mónica, Arroyo Nombela, Francisco Javier, Torre-Ruiz, Maria Angeles de la
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/130109
Acceso en línea:https://hdl.handle.net/20.500.14352/130109
Access Level:acceso abierto
Palabra clave:579
Iron homeostasis
MAPK
Slt2
Aft1
Chronological life span
Microbiología (Farmacia)
2414 Microbiología
2415.01 Biología Molecular de Microorganismos
id ES_f1950aba99df2eeef59e381cb8712c2b
oai_identifier_str oai:docta.ucm.es:20.500.14352/130109
network_acronym_str ES
network_name_str España
repository_id_str
spelling The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1Pujol-Carrion, NuriaPavón Verges, MónicaArroyo Nombela, Francisco JavierTorre-Ruiz, Maria Angeles de la579Iron homeostasisMAPKSlt2Aft1Chronological life spanMicrobiología (Farmacia)2414 Microbiología2415.01 Biología Molecular de MicroorganismosIron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions. The lack of Slt2 provokes Aft1 dysfunction leading to a shorter chronological life span. The signal of iron scarcity is not transmitted to Slt2 through other signalling pathways such as TOR1, PKA, SNF1 or TOR2/YPK1. The observation that Slt2 physically binds Aft1 rather suggests a direct regulation.ElsevierUniversidad Complutense de Madrid20212021-04-0120212021-04-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/130109reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1301092026-06-02T12:44:21Z
dc.title.none.fl_str_mv The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
title The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
spellingShingle The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
Pujol-Carrion, Nuria
579
Iron homeostasis
MAPK
Slt2
Aft1
Chronological life span
Microbiología (Farmacia)
2414 Microbiología
2415.01 Biología Molecular de Microorganismos
title_short The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
title_full The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
title_fullStr The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
title_full_unstemmed The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
title_sort The MAPK Slt2/Mpk1 plays a role in iron homeostasis through direct regulation of the transcription factor Aft1
dc.creator.none.fl_str_mv Pujol-Carrion, Nuria
Pavón Verges, Mónica
Arroyo Nombela, Francisco Javier
Torre-Ruiz, Maria Angeles de la
author Pujol-Carrion, Nuria
author_facet Pujol-Carrion, Nuria
Pavón Verges, Mónica
Arroyo Nombela, Francisco Javier
Torre-Ruiz, Maria Angeles de la
author_role author
author2 Pavón Verges, Mónica
Arroyo Nombela, Francisco Javier
Torre-Ruiz, Maria Angeles de la
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 579
Iron homeostasis
MAPK
Slt2
Aft1
Chronological life span
Microbiología (Farmacia)
2414 Microbiología
2415.01 Biología Molecular de Microorganismos
topic 579
Iron homeostasis
MAPK
Slt2
Aft1
Chronological life span
Microbiología (Farmacia)
2414 Microbiología
2415.01 Biología Molecular de Microorganismos
description Iron is an essential element for life. Cells develop mechanisms to tightly regulate its homeostasis, in order to avoid abnormal accumulation and the consequent cell toxicity. In budding yeast, the high affinity iron regulon is under the control of the transcription factor Aft1. We present evidence demonstrating that the MAPK Slt2 of the cell wall integrity pathway (CWI), phosphorylates and negatively regulates Aft1 activity upon the iron depletion signal, both in fermentative or respiratory conditions. The lack of Slt2 provokes Aft1 dysfunction leading to a shorter chronological life span. The signal of iron scarcity is not transmitted to Slt2 through other signalling pathways such as TOR1, PKA, SNF1 or TOR2/YPK1. The observation that Slt2 physically binds Aft1 rather suggests a direct regulation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-04-01
2021
2021-04-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/130109
url https://hdl.handle.net/20.500.14352/130109
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424169191473152
score 15.811543

Similares en LA Referencia