Revisiting the liver: from development to regeneration - what we ought to know!

The liver is structurally and functionally heterogeneous and complex, and it accomplishes crucial functions for the organism. Its most remarkable potential is its capacity to regenerate after injury in order to maintain whole body homeostasis and guarantee the survival of the individual. Under norma...

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Detalles Bibliográficos
Autores: López Luque, Judit, Fabregat Romero, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172851
Acceso en línea:https://hdl.handle.net/2445/172851
Access Level:acceso abierto
Palabra clave:Malalties del fetge
Hepatologia
Liver diseases
Hepatology
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spelling Revisiting the liver: from development to regeneration - what we ought to know!López Luque, JuditFabregat Romero, IsabelMalalties del fetgeHepatologiaLiver diseasesHepatologyThe liver is structurally and functionally heterogeneous and complex, and it accomplishes crucial functions for the organism. Its most remarkable potential is its capacity to regenerate after injury in order to maintain whole body homeostasis and guarantee the survival of the individual. Under normal conditions, liver regeneration (LR) is attributed to adult hepatocytes, the main cells in the liver which are able to proliferate in response to different stimuli or injuries. Nevertheless, when liver injury is severe and/or hepatocytes are prevented from proliferation, liver stem/progenitor cells (LS/PCs) participate directing LR to maintain liver mass and functions. Different mechanisms have been shown to guide this second line of LR, such as intrahepatic and extrahepatic liver progenitor cells, as well as transdifferentiation processes between hepatocytes and other liver cells. For this reason, many efforts have been made to elucidate the specific molecular mechanisms which orchestrate this process; this in turn would improve the prognosis and treatment of liver diseases. In this review, we revisit the fascinating process of LR, also with a short overview about liver development, the process from which arises the concept of LS/PCs participating in LR, and very important nowadays when considering cell therapy and tissue bioengineering for the treatment of patients suffering from liver disease.University of the Basque Country Press2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/172851Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1387/ijdb.170264JLInternational Journal of Developmental Biology, 2018, vol. 62, p. 441-451https://doi.org/10.1387/ijdb.170264JL(c) University of the Basque Country Press, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1728512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Revisiting the liver: from development to regeneration - what we ought to know!
title Revisiting the liver: from development to regeneration - what we ought to know!
spellingShingle Revisiting the liver: from development to regeneration - what we ought to know!
López Luque, Judit
Malalties del fetge
Hepatologia
Liver diseases
Hepatology
title_short Revisiting the liver: from development to regeneration - what we ought to know!
title_full Revisiting the liver: from development to regeneration - what we ought to know!
title_fullStr Revisiting the liver: from development to regeneration - what we ought to know!
title_full_unstemmed Revisiting the liver: from development to regeneration - what we ought to know!
title_sort Revisiting the liver: from development to regeneration - what we ought to know!
dc.creator.none.fl_str_mv López Luque, Judit
Fabregat Romero, Isabel
author López Luque, Judit
author_facet López Luque, Judit
Fabregat Romero, Isabel
author_role author
author2 Fabregat Romero, Isabel
author2_role author
dc.subject.none.fl_str_mv Malalties del fetge
Hepatologia
Liver diseases
Hepatology
topic Malalties del fetge
Hepatologia
Liver diseases
Hepatology
description The liver is structurally and functionally heterogeneous and complex, and it accomplishes crucial functions for the organism. Its most remarkable potential is its capacity to regenerate after injury in order to maintain whole body homeostasis and guarantee the survival of the individual. Under normal conditions, liver regeneration (LR) is attributed to adult hepatocytes, the main cells in the liver which are able to proliferate in response to different stimuli or injuries. Nevertheless, when liver injury is severe and/or hepatocytes are prevented from proliferation, liver stem/progenitor cells (LS/PCs) participate directing LR to maintain liver mass and functions. Different mechanisms have been shown to guide this second line of LR, such as intrahepatic and extrahepatic liver progenitor cells, as well as transdifferentiation processes between hepatocytes and other liver cells. For this reason, many efforts have been made to elucidate the specific molecular mechanisms which orchestrate this process; this in turn would improve the prognosis and treatment of liver diseases. In this review, we revisit the fascinating process of LR, also with a short overview about liver development, the process from which arises the concept of LS/PCs participating in LR, and very important nowadays when considering cell therapy and tissue bioengineering for the treatment of patients suffering from liver disease.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172851
url https://hdl.handle.net/2445/172851
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1387/ijdb.170264JL
International Journal of Developmental Biology, 2018, vol. 62, p. 441-451
https://doi.org/10.1387/ijdb.170264JL
dc.rights.none.fl_str_mv (c) University of the Basque Country Press, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) University of the Basque Country Press, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv University of the Basque Country Press
publisher.none.fl_str_mv University of the Basque Country Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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