Interest of 3-arylcoumarins as xanthine oxidase inhibitors

In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for furt...

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Detalles Bibliográficos
Autores: Matos, Maria João Correia Pinto Carvalho de, Borges, Fernanda, Santana Penín, María Lourdes, Uriarte Villares, Eugenio, Medda, Rosaria, Pintus, Francesca, Caboni, Martina, Era, Benedetta, Fais, Antonella, Petrillo, Amalia di
Tipo de recurso: capítulo de libro
Fecha de publicación:2015
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/25880
Acceso en línea:http://hdl.handle.net/10347/25880
Access Level:acceso abierto
Descripción
Sumario:In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout

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