Interest of 3-arylcoumarins as xanthine oxidase inhibitors

In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for furt...

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Detalhes bibliográficos
Autores: Matos, Maria João Correia Pinto Carvalho de, Borges, Fernanda, Santana Penín, María Lourdes, Uriarte Villares, Eugenio, Medda, Rosaria, Pintus, Francesca, Caboni, Martina, Era, Benedetta, Fais, Antonella, Petrillo, Amalia di
Formato: capítulo de livro
Fecha de publicación:2015
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/25880
Acesso em linha:http://hdl.handle.net/10347/25880
Access Level:acceso abierto
Descrição
Resumo:In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4’-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout