Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2

One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at synapses. Often, neurons and synapses operate at high levels of activity through sop...

Descripción completa

Detalles Bibliográficos
Autores: Lavado-Roldán, Laura, Fernández-Chacón, Rafael
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/180670
Acceso en línea:http://hdl.handle.net/10261/180670
Access Level:acceso abierto
id ES_f0e8fc2ef54e039c10e988f9bab110f2
oai_identifier_str oai:digital.csic.es:10261/180670
network_acronym_str ES
network_name_str España
repository_id_str
spelling Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2Lavado-Roldán, LauraFernández-Chacón, RafaelOne of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at synapses. Often, neurons and synapses operate at high levels of activity through sophisticated arborizations of long axons and dendrites that nevertheless stay healthy throughout years. On the other hand, aging and activity-dependent stress strike onto the protein machineries turning proteins unfolded and prone to form pathological aggregates associated with neurodegeneration. How do neurons protect from those insults and remain healthy for their whole life? Ali and colleagues now present a molecular mechanism by which the enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) acts not only as a NAD synthase involved in axonal maintenance but as a molecular chaperone helping neurons to overcome protein unfolding and protein aggregation.Research in RFC lab supported by Spanish Ministerio de Economía y Competititividad (MINECO) (BFU2013-47493) Junta de Andalucía (P12-CTS-2232), Instituto de Salud Carlos III and Fondo Europeo de Desarrollo Regional. ALR has been supported by MINECO (BES-2011-046029).Peer reviewedPublic Library of ScienceMinisterio de Economía y Competitividad (España)Junta de AndalucíaEuropean CommissionInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/180670reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-47493https://doi.org/10.1371/journal.pbio.1002522Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1806702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
title Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
spellingShingle Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
Lavado-Roldán, Laura
title_short Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
title_full Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
title_fullStr Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
title_full_unstemmed Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
title_sort Two for the Price of One: A Neuroprotective Chaperone Kit within NAD Synthase Protein NMNAT2
dc.creator.none.fl_str_mv Lavado-Roldán, Laura
Fernández-Chacón, Rafael
author Lavado-Roldán, Laura
author_facet Lavado-Roldán, Laura
Fernández-Chacón, Rafael
author_role author
author2 Fernández-Chacón, Rafael
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Junta de Andalucía
European Commission
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description One of the most fascinating properties of the brain is the ability to function smoothly across decades of a lifespan. Neurons are nondividing mature cells specialized in fast electrical and chemical communication at synapses. Often, neurons and synapses operate at high levels of activity through sophisticated arborizations of long axons and dendrites that nevertheless stay healthy throughout years. On the other hand, aging and activity-dependent stress strike onto the protein machineries turning proteins unfolded and prone to form pathological aggregates associated with neurodegeneration. How do neurons protect from those insults and remain healthy for their whole life? Ali and colleagues now present a molecular mechanism by which the enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) acts not only as a NAD synthase involved in axonal maintenance but as a molecular chaperone helping neurons to overcome protein unfolding and protein aggregation.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/180670
url http://hdl.handle.net/10261/180670
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-47493
https://doi.org/10.1371/journal.pbio.1002522
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424052676853760
score 15,812429

Similares en LA Referencia