A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants

It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various formulation strategies and lipid delivery systems have...

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Autores: Pardo de Donlebún, Blanca, Chabni, Assamae, Bañares, Celia, Torres, Carlos F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/375496
Acceso en línea:http://hdl.handle.net/10261/375496
Access Level:acceso abierto
Palabra clave:Arachidonic acid
Bio-accessibility
Docosahexaenoic acid
Enzymatic glycerolysis product
Formulations
In vitro digestion
Preterm infants
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spelling A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infantsPardo de Donlebún, BlancaChabni, AssamaeBañares, CeliaTorres, Carlos F.Arachidonic acidBio-accessibilityDocosahexaenoic acidEnzymatic glycerolysis productFormulationsIn vitro digestionPreterm infantsIt is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various formulation strategies and lipid delivery systems have been developed. This study compares the following three formulations in an in vitro digestion model to assess bioaccessibility: Enfamil® DHA & ARA (Mead Johnson & Company), an emulsion of FormulaidTM, AquaCelle®, and pasteurized donated human milk, and a previously characterized enzymatic glycerolysis product (GP) of ARA oil and microalgae oil in a 2:1 (w:w) ratio. To evaluate digestibility, parameters such as the percentage of oily phase (OP), micellar phase (MP), free fatty acids, and monoacylglycerols in the digestion product (DP) were considered. Additionally, diacylglycerol content in the MP can be used as an indirect marker of the emulsification capacity of the DP, and consequently, as an indicator of bioaccessibility. The GP demonstrated the highest bioaccessibility, with a DP containing more than 80% MP (<14% OP), rich in free fatty acids (60%) and monoacylglycerols (17%). Furthermore, more than 40% of total diacylglycerols were present in MP, highlighting GPs’ potential as a superior delivery system for DHA and ARA in preterm infant formulations.This research was funded by Fundación Ramón Areces (CIVP20A6607) and Ministerio de Ciencia e Innovación (project number PID2020-119084RB-C21).Peer reviewedMultidisciplinary Digital Publishing InstituteFundación Ramón ArecesMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520242025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/375496reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119084RB-C21The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/molecules29246032https://doi.org/10.3390/molecules29246032Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3754962026-05-22T06:33:51Z
dc.title.none.fl_str_mv A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
title A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
spellingShingle A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
Pardo de Donlebún, Blanca
Arachidonic acid
Bio-accessibility
Docosahexaenoic acid
Enzymatic glycerolysis product
Formulations
In vitro digestion
Preterm infants
title_short A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
title_full A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
title_fullStr A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
title_full_unstemmed A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
title_sort A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
dc.creator.none.fl_str_mv Pardo de Donlebún, Blanca
Chabni, Assamae
Bañares, Celia
Torres, Carlos F.
author Pardo de Donlebún, Blanca
author_facet Pardo de Donlebún, Blanca
Chabni, Assamae
Bañares, Celia
Torres, Carlos F.
author_role author
author2 Chabni, Assamae
Bañares, Celia
Torres, Carlos F.
author2_role author
author
author
dc.contributor.none.fl_str_mv Fundación Ramón Areces
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Arachidonic acid
Bio-accessibility
Docosahexaenoic acid
Enzymatic glycerolysis product
Formulations
In vitro digestion
Preterm infants
topic Arachidonic acid
Bio-accessibility
Docosahexaenoic acid
Enzymatic glycerolysis product
Formulations
In vitro digestion
Preterm infants
description It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various formulation strategies and lipid delivery systems have been developed. This study compares the following three formulations in an in vitro digestion model to assess bioaccessibility: Enfamil® DHA & ARA (Mead Johnson & Company), an emulsion of FormulaidTM, AquaCelle®, and pasteurized donated human milk, and a previously characterized enzymatic glycerolysis product (GP) of ARA oil and microalgae oil in a 2:1 (w:w) ratio. To evaluate digestibility, parameters such as the percentage of oily phase (OP), micellar phase (MP), free fatty acids, and monoacylglycerols in the digestion product (DP) were considered. Additionally, diacylglycerol content in the MP can be used as an indirect marker of the emulsification capacity of the DP, and consequently, as an indicator of bioaccessibility. The GP demonstrated the highest bioaccessibility, with a DP containing more than 80% MP (<14% OP), rich in free fatty acids (60%) and monoacylglycerols (17%). Furthermore, more than 40% of total diacylglycerols were present in MP, highlighting GPs’ potential as a superior delivery system for DHA and ARA in preterm infant formulations.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/375496
url http://hdl.handle.net/10261/375496
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119084RB-C21
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/molecules29246032
https://doi.org/10.3390/molecules29246032
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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