A comparative in vitro digestion study of three lipid delivery systems for arachidonic and docosahexaenoic acids intended to be used for preterm infants
It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various formulation strategies and lipid delivery systems have...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/718281 |
| Acceso en línea: | http://hdl.handle.net/10486/718281 https://dx.doi.org/10.3390/molecules29246032 |
| Access Level: | acceso abierto |
| Palabra clave: | arachidonic acid bio-accessibility docosahexaenoic acid enzymatic glycerolysis product formulations in vitro digestion preterm infants Ciencia y Tecnología de Alimentos |
| Sumario: | It is well stablished that docosahexaenoic (DHA) and arachidonic (ARA) acids fulfill relevant biological activities, especially in newborns. However, oils containing these fatty acids are not always optimally digestible. To address this, various formulation strategies and lipid delivery systems have been developed. This study compares the following three formulations in an in vitro digestion model to assess bioaccessibility: Enfamil® DHA & ARA (Mead Johnson & Company), an emulsion of FormulaidTM, AquaCelle®, and pasteurized donated human milk, and a previously characterized enzymatic glycerolysis product (GP) of ARA oil and microalgae oil in a 2:1 (w:w) ratio. To evaluate digestibility, parameters such as the percentage of oily phase (OP), micellar phase (MP), free fatty acids, and monoacylglycerols in the digestion product (DP) were considered. Additionally, diacylglycerol content in the MP can be used as an indirect marker of the emulsification capacity of the DP, and consequently, as an indicator of bioacc |
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