Pediatric Community-Acquired Bone and Joint Staphylococcus Aureus Infections In Europe Severe Infections are Associated to Panton-Valentine Leucocidin Presence

To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Pan...

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Detalles Bibliográficos
Autores: Gijón M, Bellusci M, Petraitiene B, Noguera-Julian A, Glikman D, Saavedra-Lozano J, Neth O, Daskalaki M, Zilinskaite V, Kaiser-Labusch P, Prieto L, Rojo P
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p17538
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17538
Access Level:acceso abierto
Palabra clave:aureus
children
osteomyelitis
arthritis
PVL
Descripción
Sumario:To analyze host and pathogen factors related to disease severity of community-acquired bone and joint infections in children, a cohort of pediatric patients was prospectively recruited from 13 centers in 7 European countries. A total of 85 children were included, 11 (13%) had a severe infection. Panton-Valentine leukocidin-positive isolates were 17%, and 6% of the isolates were methicillin-resistant Staphylococcus aureus. Multivariate analysis identified Panton-Valentine leukocidin presence (adjusted odds ratio, 12.6; P = 0.01) as the only factor independently associated with severe outcome, regardless of methicillin resistance.

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