Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria

7 Pág.

Detalles Bibliográficos
Autor: Landete, José María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/270515
Acceso en línea:http://hdl.handle.net/10261/270515
https://api.elsevier.com/content/abstract/scopus_id/85129279372
Access Level:acceso abierto
Palabra clave:6-Hydroxy-O-desmethylangolesin
Engineered lactic acid bacteria
O-desmethylangolesin
Soy beverages
Probiotic
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spelling Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteriaLandete, José María6-Hydroxy-O-desmethylangolesinEngineered lactic acid bacteriaO-desmethylangolesinSoy beveragesProbiotic7 Pág.The main isoflavones in food are daidzin and genistin, which must be deglycosylated into daidzein and genistein to increase their biological activity and bioavailability. Later, daidzein can be transformed into O-desmethylangolensin (O-DMA) and/or equol, while genistein can originate 6-hydroxy-desmethylangolensin (6-OH-O-DMA) and/or 5-hydroxy-equol. The objective was to understand the metabolism of O-DMA and 6-OH-O-DMA by lactic acid bacteria (LAB) to increase the concentration of both compounds in fermented beverages due to their ability to inhibit the proliferation of cancer cells and improve the antioxidant activity. Assays with different engineered LAB strains showed that O-DMA and 6-OH-O-DMA are produced by LAB mainly from daidzein and genistein, respectively, by fission of the C-ring. O-DMA and 6-OH-O-DMA producing LAB harbouring pNZ:TuR.gly913, or the food grade vector pLEB590.gly913, both with the glucosidase gen gly913, increased the production of O-DMA and 6-OH-O-DMA in addition to daidzein and genistein. Moreover, the combination of O-DMA and 6-OH-O-DMA producing LAB with potential probiotic properties, and a bifidobacteria strain with high deglycosydase activity, allowed the development of probiotic soy beverages enriched in O-DMA, 6-OH-O-DMA, daidzein and genistein. Soy beverages enriched in O-DMA, 6-OH-O-DMA, daidzein and genistein would be of value for the development of functional foods.This work was supported by projects RTA2017-00002-00-00 and PID2020-11960RB-I00 from the Spanish Ministry of Science, Innovation and Universities.Peer reviewedElsevierMinisterio de Ciencia, Innovación y Universidades (España)Landete, José María [0000-0002-5147-3989]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/270515https://api.elsevier.com/content/abstract/scopus_id/85129279372reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN/RTA2017-00002-00-00/info:eu-repo/grantAgreement/MICINN/PID2020-11960RB-I00/LWThttps://doi.org/10.1016/j.lwt.2022.113526Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2705152026-05-22T06:33:51Z
dc.title.none.fl_str_mv Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
title Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
spellingShingle Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
Landete, José María
6-Hydroxy-O-desmethylangolesin
Engineered lactic acid bacteria
O-desmethylangolesin
Soy beverages
Probiotic
title_short Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
title_full Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
title_fullStr Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
title_full_unstemmed Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
title_sort Development of soy beverages enriched in O-desmethylangolesin and 6-hydroxy-O-desmethylangolesin by engineered lactic acid bacteria
dc.creator.none.fl_str_mv Landete, José María
author Landete, José María
author_facet Landete, José María
author_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Landete, José María [0000-0002-5147-3989]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv 6-Hydroxy-O-desmethylangolesin
Engineered lactic acid bacteria
O-desmethylangolesin
Soy beverages
Probiotic
topic 6-Hydroxy-O-desmethylangolesin
Engineered lactic acid bacteria
O-desmethylangolesin
Soy beverages
Probiotic
description 7 Pág.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/270515
https://api.elsevier.com/content/abstract/scopus_id/85129279372
url http://hdl.handle.net/10261/270515
https://api.elsevier.com/content/abstract/scopus_id/85129279372
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN/RTA2017-00002-00-00/
info:eu-repo/grantAgreement/MICINN/PID2020-11960RB-I00/
LWT
https://doi.org/10.1016/j.lwt.2022.113526
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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