Studying the effect of vaccination in epidemic models with stochastic transmission
Mathematical epidemic models are frequently used in biology for analyzing transmission dynamics of infectious diseases and assessing control measures to interrupt their expansion. In order to select and develop properly the above mathematical models, it is necessary to take into account the particul...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/4169 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/4169 |
| Access Level: | acceso abierto |
| Palabra clave: | 614.47(043.2) Vaccination Vacunación Salud pública (Medicina) 3212 Salud Pública |
| Sumario: | Mathematical epidemic models are frequently used in biology for analyzing transmission dynamics of infectious diseases and assessing control measures to interrupt their expansion. In order to select and develop properly the above mathematical models, it is necessary to take into account the particularities of an epidemic process as type of disease, mode of transmission and population characteristics. In this thesis we focus on infectious diseases with stochastic transmission including vaccination as a control measure to stop the spread of the pathogen. To that end, we consider constant and moderate size populations where individuals are homogeneously mixed. We assume that characteristics related to the transmission/recovery of the infectious disease present a common probabilistic behavior for individuals in the population. To assure herd immunity protection, we consider that a percentage of the population is protected against the disease by a vaccine, prior to the start of the outbreak.The administered vaccine is imperfect in the sense that some individuals, who have been previously vaccinated, failed to increase antibody levels and, in consequence, they could be infected. Pathogenic transmission occurs by direct contact with infected individuals. As population is not isolated, disease spreads from direct contacts with infected individuals inside or outside the population... |
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