Age-related differences in cardiogenic shock secondary to Takotsubo syndrome

Background Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS).Methods and Results We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age...

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Detalles Bibliográficos
Autores: Tomasino, M, Vazirani, R, Salamanca, J, Raposeiras-Roubin, S, Fernández-Cordón, C, Corbí-Pascual, M, Vedia, O, Martín-García, AC, Blanco-Ponce, E, Delia, MA, Piserra-López, A, Guerra, JFL, Gonzalez-Santorum, F, Lluch-Requerey, C, Guillén-Marzo, M, Pérez-Castellanos, A, Ridocci-Soriano, F, Lopez-País, J, Andrea, R, Sionis, A, Núñez-Gil, IJ, Uribarri, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p21172
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21172
Access Level:acceso abierto
Palabra clave:age-related differences
cardiogenic shock
heart failure
left ventricular dysfunction
stress cardiomyopathy
Takotsubo
Descripción
Sumario:Background Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS).Methods and Results We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: <= 50 years (9%), 51-74 years (48%), and >= 75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p = .01), have a physical trigger (65% vs. 43% and 49%, p = .04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p = .02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p = .01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p = .15). Older age independently predicted both in-hospital mortality (OR 2.33, 95% CI 1.05-5.17; reference: middle-aged) and 5-year mortality (HR 3.69, 95% CI 1.77-7.67), regardless of shock severity.Conclusions In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS.

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