Early clinical trials in paediatric oncology in Spain: a nationwide perspective

[Introduction] Cancer is the leading cause of death between the first year of life and adolescence, and some types of diseases are still a major challenge in terms of cure. There is, therefore, a major need for new drugs. Recent findings in cancer biology open the door to the development of targeted...

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Detalles Bibliográficos
Autores: Bautista, Francisco, Gallego, Soledad, Cañete, Adela, Mora, Jaume, Díaz de Heredia, Cristina, Cruz, Ofelia, Fernández, José M., Rives, Susana, Berlanga, Pablo, Hladun, Raquel, Ribelles, Antonio Juan, Madero, Luis, Ramírez, Manuel, Fernández Delgado, Rafael, Pérez-Martínez, Antonio, Mata, Cristina, Llort, Anna, Martín-Broto, Javier, Cela, María Elena, Ramírez, Gema, Sábado, Constantino, Acha, Tomás, Astigarraga, Itziar, Sastre, Ana, Muñoz, Ascensión, Guibelalde, Mercedes, Moreno, Lucas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/182443
Acceso en línea:http://hdl.handle.net/10261/182443
Access Level:acceso abierto
Palabra clave:Oncología y hematología pediátrica
Ensayos clínicos precoces
Desarrollo de nuevos fármacos
Medicina personalizada
Paediatric haematology and oncology
Early phase clinical trials
Drug development
Personalised medicine
Descripción
Sumario:[Introduction] Cancer is the leading cause of death between the first year of life and adolescence, and some types of diseases are still a major challenge in terms of cure. There is, therefore, a major need for new drugs. Recent findings in cancer biology open the door to the development of targeted therapies against individual molecular changes, as well as immunotherapy. Promising results in adult anti-cancer drug development have not yet been translated into paediatric clinical practice. A report is presented on the activity in early paediatric oncology trials (phase I-II) in Spain.

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