Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease
© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any m...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/352235 |
| Acceso en línea: | http://hdl.handle.net/10261/352235 |
| Access Level: | acceso abierto |
| Palabra clave: | [123I]FP-CIT SPECT Inflammation Neurodegeneration Neutrophil-to-lymphocyte ratio Parkinson's disease |
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Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| title |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| spellingShingle |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease Muñoz-Delgado, Laura [123I]FP-CIT SPECT Inflammation Neurodegeneration Neutrophil-to-lymphocyte ratio Parkinson's disease |
| title_short |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| title_full |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| title_fullStr |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| title_full_unstemmed |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| title_sort |
Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's Disease |
| dc.creator.none.fl_str_mv |
Muñoz-Delgado, Laura Labrador, Miguel Ángel Macías García, Daniel Jesús Maestre, Silvia Benítez Zamora, Belén Fernández-Rodríguez, Paula Adarmes-Gómez, Astrid Reina-Castillo, María Isabel Castro-Labrador, Sandra Silva-Rodríguez, Jesús Carrillo, Fátima García-Solís, David Grothe, Michel J. Mir, Pablo |
| author |
Muñoz-Delgado, Laura |
| author_facet |
Muñoz-Delgado, Laura Labrador, Miguel Ángel Macías García, Daniel Jesús Maestre, Silvia Benítez Zamora, Belén Fernández-Rodríguez, Paula Adarmes-Gómez, Astrid Reina-Castillo, María Isabel Castro-Labrador, Sandra Silva-Rodríguez, Jesús Carrillo, Fátima García-Solís, David Grothe, Michel J. Mir, Pablo |
| author_role |
author |
| author2 |
Labrador, Miguel Ángel Macías García, Daniel Jesús Maestre, Silvia Benítez Zamora, Belén Fernández-Rodríguez, Paula Adarmes-Gómez, Astrid Reina-Castillo, María Isabel Castro-Labrador, Sandra Silva-Rodríguez, Jesús Carrillo, Fátima García-Solís, David Grothe, Michel J. Mir, Pablo |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Junta de Andalucía Instituto de Salud Carlos III European Commission Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
[123I]FP-CIT SPECT Inflammation Neurodegeneration Neutrophil-to-lymphocyte ratio Parkinson's disease |
| topic |
[123I]FP-CIT SPECT Inflammation Neurodegeneration Neutrophil-to-lymphocyte ratio Parkinson's disease |
| description |
© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
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2023 |
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2023 2024 2024 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10261/352235 |
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http://hdl.handle.net/10261/352235 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# #PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/MINECO//PI16%2F01575 info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01898 info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01576 info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00613 info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F01875 info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F01704 The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1002/mds.29369 https://doi.org/10.1002/mds.29369 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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John Wiley & Sons |
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John Wiley & Sons |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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Peripheral Inflammation Is Associated with Dopaminergic Degeneration in Parkinson's DiseaseMuñoz-Delgado, LauraLabrador, Miguel ÁngelMacías García, DanielJesús Maestre, SilviaBenítez Zamora, BelénFernández-Rodríguez, PaulaAdarmes-Gómez, AstridReina-Castillo, María IsabelCastro-Labrador, SandraSilva-Rodríguez, JesúsCarrillo, FátimaGarcía-Solís, DavidGrothe, Michel J.Mir, Pablo[123I]FP-CIT SPECTInflammationNeurodegenerationNeutrophil-to-lymphocyte ratioParkinson's disease© 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.[Background] Peripheral inflammatory immune responses are suggested to play a major role in dopaminergic degeneration in Parkinson's disease (PD). The neutrophil-to-lymphocyte ratio (NLR) is a well-established biomarker of systemic inflammation in PD. Degeneration of the nigrostriatal dopaminergic system can be assessed in vivo using [123I]FP-CIT single photon emission computed tomography imaging of striatal dopamine transporter (DAT) density.[Objectives] To assess the relationship between the peripheral immune profile (NLR, lymphocytes, and neutrophils) and striatal DAT density in patients with PD.[Methods] We assessed clinical features, the peripheral immune profile, and striatal [123I]FP-CIT DAT binding levels of 211 patients with PD (primary-cohort). Covariate-controlled associations between the immune response and striatal DAT levels were assessed using linear regression analyses. For replication purposes, we also studied a separate cohort of 344 de novo patients with PD enrolled in the Parkinson's Progression Markers Initiative (PPMI-cohort).[Results] A higher NLR was significantly associated with lower DAT levels in the caudate (primary-cohort: β = −0.01, p < 0.001; PPMI-cohort: β = −0.05, p = 0.05) and the putamen (primary-cohort: β = −0.05, p = 0.02; PPMI-cohort: β = −0.06, p = 0.02). Intriguingly, a lower lymphocyte count was significantly associated with lower DAT levels in both the caudate (primary-cohort: β = +0.09, p < 0.05; PPMI-cohort: β = +0.11, p = 0.02) and the putamen (primary-cohort: β = +0.09, p < 0.05, PPMI-cohort: β = +0.14, p = 0.01), but an association with the neutrophil count was not consistently observed (caudate; primary-cohort: β = −0.05, p = 0.02; PPMI-cohort: β = 0, p = 0.94; putamen; primary-cohort: β = −0.04, p = 0.08; PPMI-cohort: β = −0.01, p = 0.73).[Conclusions] Our findings across two independent cohorts suggest a relationship between systemic inflammation and dopaminergic degeneration in patients with PD. This relationship was mainly driven by the lymphocyte count. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía. Grant Numbers: CTS-7685, CVI-02526Consejería de Salud y Bienestar Social de la Junta de Andalucía. Grant Numbers: PE-0186-2019, PE-0210-2018, PI-0459-2018, PI-0471-2013Consejería de Transformación Económica, Industria, Conocimiento y Universidades de la Junta de Andalucía. Grant Number: PY20_00896Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (ISCIII-FEDER). Grant Numbers: PI16/01575, PI18/01898, PI19/01576, PI20/00613, PI21/01875, PI22/01704Peer reviewedJohn Wiley & SonsJunta de AndalucíaInstituto de Salud Carlos IIIEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/352235reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//PI16%2F01575info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01898info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F01576info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00613info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI21%2F01875info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/PI22%2F01704The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1002/mds.29369https://doi.org/10.1002/mds.29369Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3522352026-05-22T06:33:51Z |
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15,812429 |