Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease

Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild...

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Autores: Páez, Arsenio, Gillman, Sam O., Dogaheh, Shahla Bakian, Carnes Vendrell, Anna, Dakterzada, Farida, Barbé Illa, Ferran, Dang-Vu, Thien Thanh, Piñol Ripoll, Gerard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/467946
Acceso en línea:https://doi.org/10.1002/alz.14424
https://hdl.handle.net/10459.1/467946
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid beta
Biomarkers
Cognition
Cognitive decline
Sleep
Sleep spindles
Slow oscillations
Tau
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spelling Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's diseasePáez, ArsenioGillman, Sam O.Dogaheh, Shahla BakianCarnes Vendrell, AnnaDakterzada, FaridaBarbé Illa, FerranDang-Vu, Thien ThanhPiñol Ripoll, GerardAlzheimer's diseaseAmyloid betaBiomarkersCognitionCognitive declineSleepSleep spindlesSlow oscillationsTauIntroduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye movement sleep spindles and slow oscillations (SOs) at baseline and their associations with baseline amyloid beta (Aβ) and tau and with cognition from baseline to 3-year follow-up. Results: Higher spindle and SO activity predicted significant changes in Aβ and tau at baseline, lower Alzheimer's Disease Assessment Scale Cognitive Subscale (better cognitive performance) score, and higher Mini-Mental State Examination score from baseline to 36 months. Spindles and SOs mediated the effect of phosphorylated tau 181 (pTau181)/Aβ42 on cognition, while pTau181/aβ42 moderated the effect of spindles and SOs on cognition. Discussion: Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non-invasive biomarkers of neurodegeneration and cognition in AD patients. Highlights: Sleep spindles predict long-term cognitive performance in AD. Sleep spindle and SOs can be predictive, non-invasive biomarkers for AD. Sleep may be one of the most important modifiable risk factors for AD progression. Sleep microarchitecture is a novel therapeutic target for preserving brain heath. Sleep physiology can provide novel therapeutic targets to slow AD progression.Wiley2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1002/alz.14424https://hdl.handle.net/10459.1/467946reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.1002/alz.14424Alzheimer's & Dementia, 2025, vol. 21, núm. 2, e14424cc-by (c) The Authors, 2025Attribution 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4679462026-06-24T12:42:17Z
dc.title.none.fl_str_mv Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
title Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
spellingShingle Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
Páez, Arsenio
Alzheimer's disease
Amyloid beta
Biomarkers
Cognition
Cognitive decline
Sleep
Sleep spindles
Slow oscillations
Tau
title_short Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
title_full Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
title_fullStr Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
title_full_unstemmed Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
title_sort Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
dc.creator.none.fl_str_mv Páez, Arsenio
Gillman, Sam O.
Dogaheh, Shahla Bakian
Carnes Vendrell, Anna
Dakterzada, Farida
Barbé Illa, Ferran
Dang-Vu, Thien Thanh
Piñol Ripoll, Gerard
author Páez, Arsenio
author_facet Páez, Arsenio
Gillman, Sam O.
Dogaheh, Shahla Bakian
Carnes Vendrell, Anna
Dakterzada, Farida
Barbé Illa, Ferran
Dang-Vu, Thien Thanh
Piñol Ripoll, Gerard
author_role author
author2 Gillman, Sam O.
Dogaheh, Shahla Bakian
Carnes Vendrell, Anna
Dakterzada, Farida
Barbé Illa, Ferran
Dang-Vu, Thien Thanh
Piñol Ripoll, Gerard
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer's disease
Amyloid beta
Biomarkers
Cognition
Cognitive decline
Sleep
Sleep spindles
Slow oscillations
Tau
topic Alzheimer's disease
Amyloid beta
Biomarkers
Cognition
Cognitive decline
Sleep
Sleep spindles
Slow oscillations
Tau
description Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye movement sleep spindles and slow oscillations (SOs) at baseline and their associations with baseline amyloid beta (Aβ) and tau and with cognition from baseline to 3-year follow-up. Results: Higher spindle and SO activity predicted significant changes in Aβ and tau at baseline, lower Alzheimer's Disease Assessment Scale Cognitive Subscale (better cognitive performance) score, and higher Mini-Mental State Examination score from baseline to 36 months. Spindles and SOs mediated the effect of phosphorylated tau 181 (pTau181)/Aβ42 on cognition, while pTau181/aβ42 moderated the effect of spindles and SOs on cognition. Discussion: Our findings demonstrate that spindle and SO activity during sleep constitute predictive and non-invasive biomarkers of neurodegeneration and cognition in AD patients. Highlights: Sleep spindles predict long-term cognitive performance in AD. Sleep spindle and SOs can be predictive, non-invasive biomarkers for AD. Sleep may be one of the most important modifiable risk factors for AD progression. Sleep microarchitecture is a novel therapeutic target for preserving brain heath. Sleep physiology can provide novel therapeutic targets to slow AD progression.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1002/alz.14424
https://hdl.handle.net/10459.1/467946
url https://doi.org/10.1002/alz.14424
https://hdl.handle.net/10459.1/467946
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/alz.14424
Alzheimer's & Dementia, 2025, vol. 21, núm. 2, e14424
dc.rights.none.fl_str_mv cc-by (c) The Authors, 2025
Attribution 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) The Authors, 2025
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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