Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?

Adrenocortical cancer; Checkpoint inhibitors; Metastatic paraganglioma

Detalles Bibliográficos
Autores: Jimenez, Camilo, Armaiz-Pena, Gustavo, Dahia, Patricia, Lu, Yang, De Almeida Toledo, Rodrigo, Varghese, Jeena, Habra, Mouhammed Amir
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8792
Acceso en línea:https://hdl.handle.net/11351/8792
Access Level:acceso abierto
Palabra clave:Tumors neuroendocrins
Immunoteràpia
Glàndules endocrines - Càncer
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
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spelling Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?Jimenez, CamiloArmaiz-Pena, GustavoDahia, PatriciaLu, YangDe Almeida Toledo, RodrigoVarghese, JeenaHabra, Mouhammed AmirTumors neuroendocrinsImmunoteràpiaGlàndules endocrines - CàncerDISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine TumorsDISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland NeoplasmsANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::ImmunotherapyENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinosENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinasTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapiaAdrenocortical cancer; Checkpoint inhibitors; Metastatic paragangliomaCáncer adrenocortical; Inhibidores de puntos de control; Paraganglioma metastásicoCàncer adrenocortical; Inhibidors de punts de control; Paraganglioma metastàticAdrenocortical cancers and metastatic pheochromocytomas are the most common malignancies originating in the adrenal glands. Metastatic paragangliomas are extra-adrenal tumors that share similar genetic and molecular profiles with metastatic pheochromocytomas and, subsequently, these tumors are studied together. Adrenocortical cancers and metastatic pheochromocytomas and paragangliomas are orphan diseases with limited therapeutic options worldwide. As in any other cancers, adrenocortical cancers and metastatic pheochromocytomas and paragangliomas avoid the immune system. Hypoxia-pseudohypoxia, activation of the PD-1/PD-L1 pathway, and/or microsatellite instability suggest that immunotherapy with checkpoint inhibitors could be a therapeutic option for patients with these tumors. The results of clinical trials with checkpoint inhibitors for adrenocortical carcinoma or metastatic pheochromocytoma or paraganglioma demonstrate limited benefits; nevertheless, these results also suggest interesting mechanisms that might enhance clinical responses to checkpoint inhibitors. These mechanisms include the normalization of tumor vasculature, modification of the hormonal environment, and vaccination with specific tumor antigens. Combinations of checkpoint inhibitors with classical therapies, such as chemotherapy, tyrosine kinase inhibitors, radiopharmaceuticals, and/or novel therapies, such as vaccines, should be evaluated in clinical trials.MDPIInstitut Català de la Salut[Jimenez C, Varghese J, Habra MA] Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [Armaiz-Pena G] Division of Endocrinology, Department Medicine, The University of Texas Health Science Center, San Antonio, TX, USA. [Dahia PLM] Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA. Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA. [Lu Y] Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [Almeida Toledo R] Gastrointestinal and Endocrine Tumors, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. CIBERONC, Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8792Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésCancers;14(3)https://doi.org/10.3390/cancers14030467Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/87922026-06-12T09:38:37Z
dc.title.none.fl_str_mv Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
title Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
spellingShingle Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
Jimenez, Camilo
Tumors neuroendocrins
Immunoteràpia
Glàndules endocrines - Càncer
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
title_short Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
title_full Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
title_fullStr Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
title_full_unstemmed Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
title_sort Endocrine and Neuroendocrine Tumors Special Issue—Checkpoint Inhibitors for Adrenocortical Carcinoma and Metastatic Pheochromocytoma and Paraganglioma: Do They Work?
dc.creator.none.fl_str_mv Jimenez, Camilo
Armaiz-Pena, Gustavo
Dahia, Patricia
Lu, Yang
De Almeida Toledo, Rodrigo
Varghese, Jeena
Habra, Mouhammed Amir
author Jimenez, Camilo
author_facet Jimenez, Camilo
Armaiz-Pena, Gustavo
Dahia, Patricia
Lu, Yang
De Almeida Toledo, Rodrigo
Varghese, Jeena
Habra, Mouhammed Amir
author_role author
author2 Armaiz-Pena, Gustavo
Dahia, Patricia
Lu, Yang
De Almeida Toledo, Rodrigo
Varghese, Jeena
Habra, Mouhammed Amir
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Jimenez C, Varghese J, Habra MA] Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [Armaiz-Pena G] Division of Endocrinology, Department Medicine, The University of Texas Health Science Center, San Antonio, TX, USA. [Dahia PLM] Department of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA. Mays Cancer Center, University of Texas Health San Antonio, San Antonio, TX, USA. [Lu Y] Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [Almeida Toledo R] Gastrointestinal and Endocrine Tumors, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. CIBERONC, Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Tumors neuroendocrins
Immunoteràpia
Glàndules endocrines - Càncer
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
topic Tumors neuroendocrins
Immunoteràpia
Glàndules endocrines - Càncer
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors
DISEASES::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células germinales y embrionarias::tumores neuroectodérmicos::tumores neuroendocrinos
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de las glándulas endocrinas
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
description Adrenocortical cancer; Checkpoint inhibitors; Metastatic paraganglioma
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8792
url https://hdl.handle.net/11351/8792
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancers;14(3)
https://doi.org/10.3390/cancers14030467
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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