The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1

The Smad Ubiquitin Regulatory Factor-1: SMURF1 is an E3 ligase. This E3 ligase has been linked to several important biological pathways, including the bone morphogenetic protein pathway, the non-canonical Wnt pathway and the mitogen-activated protein kinase pathway. Multiple functions of Smurf1 have...

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Detalhes bibliográficos
Autor: Muñiz Diego, María del Carmen
Tipo de documento: dissertação
Data de publicação:2013
País:España
Recursos:Universidad de Cantabria (UC)
Repositório:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglês
OAI Identifier:oai:repositorio.unican.es:10902/4198
Acesso em linha:http://hdl.handle.net/10902/4198
Access Level:Acceso aberto
Palavra-chave:Smad Ubiquitin Regulatory Factor-1
Ligasas
Ligases
SMURF1
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spelling The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1Muñiz Diego, María del CarmenSmad Ubiquitin Regulatory Factor-1LigasasLigasesSMURF1The Smad Ubiquitin Regulatory Factor-1: SMURF1 is an E3 ligase. This E3 ligase has been linked to several important biological pathways, including the bone morphogenetic protein pathway, the non-canonical Wnt pathway and the mitogen-activated protein kinase pathway. Multiple functions of Smurf1 have been discovered in cell growth and morphogenesis, cell migration, cell polarity and autophagy. Previous studies, in 2003, have demonstrated that overexpression of Smurf1 induces proteasomal degradation of Smad1 and Runx2 proteins. Runx-2 is a transcription factor that is essential for osteoblastic differentiation, bone formation and maintenance. Both the pre-adipocyte and osteoblast cells are originated from common mesenchymal progenitor cells and it has been recently demonstrated that Runx2 is also involved in adipocyte differentiation. The major goal of this project is the study the role which Smurf1 plays in the differentiation of 3T3L1 cells.Máster en Biología Molecular y BiomedicinaRodríguez Rey, José CarlosUniversidad de Cantabria20132013-01-01master thesishttp://purl.org/coar/resource_type/c_bdccNAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/masterThesishttp://hdl.handle.net/10902/4198reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/41982026-06-02T12:39:31Z
dc.title.none.fl_str_mv The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
title The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
spellingShingle The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
Muñiz Diego, María del Carmen
Smad Ubiquitin Regulatory Factor-1
Ligasas
Ligases
SMURF1
title_short The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
title_full The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
title_fullStr The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
title_full_unstemmed The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
title_sort The role of Smad Ubiquitin Regulatory Factor-1: SMURF1 in the differentiation 3T3-L1
dc.creator.none.fl_str_mv Muñiz Diego, María del Carmen
author Muñiz Diego, María del Carmen
author_facet Muñiz Diego, María del Carmen
author_role author
dc.contributor.none.fl_str_mv Rodríguez Rey, José Carlos
Universidad de Cantabria
dc.subject.none.fl_str_mv Smad Ubiquitin Regulatory Factor-1
Ligasas
Ligases
SMURF1
topic Smad Ubiquitin Regulatory Factor-1
Ligasas
Ligases
SMURF1
description The Smad Ubiquitin Regulatory Factor-1: SMURF1 is an E3 ligase. This E3 ligase has been linked to several important biological pathways, including the bone morphogenetic protein pathway, the non-canonical Wnt pathway and the mitogen-activated protein kinase pathway. Multiple functions of Smurf1 have been discovered in cell growth and morphogenesis, cell migration, cell polarity and autophagy. Previous studies, in 2003, have demonstrated that overexpression of Smurf1 induces proteasomal degradation of Smad1 and Runx2 proteins. Runx-2 is a transcription factor that is essential for osteoblastic differentiation, bone formation and maintenance. Both the pre-adipocyte and osteoblast cells are originated from common mesenchymal progenitor cells and it has been recently demonstrated that Runx2 is also involved in adipocyte differentiation. The major goal of this project is the study the role which Smurf1 plays in the differentiation of 3T3L1 cells.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01
dc.type.none.fl_str_mv master thesis
http://purl.org/coar/resource_type/c_bdcc
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/4198
url http://hdl.handle.net/10902/4198
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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