Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce

We present an analytical method developed and validated to study the potential uptake of 13 selected drugs (ten pharmaceuticals, one illicit drug, and two transformation products) into lettuce plants from contaminated water and soil. Some of the selected drugs (i.e., cocaine, methadone, cis-diltiaze...

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Autores: Montemurro, Nicola, Postigo, Cristina, Lonigro, Antonio, Pérez Solsona, Sandra, Barceló, Damià
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/152206
Acceso en línea:http://hdl.handle.net/10261/152206
Access Level:acceso abierto
Palabra clave:Illicit drugs
Liquid chromatography–mass spectrometry
Online solid-phase extraction
Pharmaceuticals
Plant uptake
Ultrasound extraction
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spelling Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuceMontemurro, NicolaPostigo, CristinaLonigro, AntonioPérez Solsona, SandraBarceló, DamiàIllicit drugsLiquid chromatography–mass spectrometryOnline solid-phase extractionPharmaceuticalsPlant uptakeUltrasound extractionWe present an analytical method developed and validated to study the potential uptake of 13 selected drugs (ten pharmaceuticals, one illicit drug, and two transformation products) into lettuce plants from contaminated water and soil. Some of the selected drugs (i.e., cocaine, methadone, cis-diltiazem, valsartan, and valsartan acid), which are commonly present in treated wastewater, were investigated for the first time in plant tissues. The method is based on ultrasonic solvent extraction with acetonitrile–methanol (1:1, v/v) and subsequent automated extract cleanup and analysis by means of online solid-phase extraction–liquid chromatography–tandem mass spectrometry. Optimum extraction conditions were selected after evaluation of analyte recoveries with four different extraction techniques (ultrasonic solvent extraction, solid–liquid extraction, pressurized liquid extraction, and a “quick, easy, cheap, effective, rugged, and safe” based method) and six different solvent mixtures. Furthermore, two different solid-phase extraction cleanup sorbents were evaluated. The method developed has high sensitivity (with limits of detection between 0.1 and 12.6 ng per gram dry weight and limits of quantification between 0.5 and 42.0 ng per gram dry weight), satisfactory accuracy (with analyte relative recoveries above 80% for all analytes but acridone and oxcarbazepine), and good repeatability (with relative standard deviations below 9% for all analytes). As part of the validation procedure, the analytical method was applied to the analysis of lettuce plants irrigated with water fortified with the selected compounds for the entire growing period. The results obtained evidenced the transfer of all the investigated drugs into lettuce leaves. [Figure not available: see fulltext.] © 2017 Springer-Verlag Berlin HeidelbergN.M. gratefully acknowledges the University of Bari for financial support provided through a predoctoral grant (29th Doctorate Program in Biodiversity, Agriculture and Environment). This work was financially supported by the Government of Catalonia (Consolidated Research Groups B2014 SGR 418—Water and Soil Quality Unit and B2014 SGR 291—Catalan Institute for Water Research), and by the EU’s Seventh Framework Programme for research, technological development and demonstration (grant agreement no. 603437—SOLUTIONS), and it reflects only the authors’ views. The EU is not liable for any use that may be made of the information contained herein. Merck is acknowledged for the gift of liquid chromatography columns.Peer reviewedSpringer NatureEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720172017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/152206reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/60343710.1007/s00216-017-0363-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1522062026-05-22T06:33:51Z
dc.title.none.fl_str_mv Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
title Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
spellingShingle Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
Montemurro, Nicola
Illicit drugs
Liquid chromatography–mass spectrometry
Online solid-phase extraction
Pharmaceuticals
Plant uptake
Ultrasound extraction
title_short Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
title_full Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
title_fullStr Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
title_full_unstemmed Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
title_sort Development and validation of an analytical method based on liquid chromatography–tandem mass spectrometry detection for the simultaneous determination of 13 relevant wastewater-derived contaminants in lettuce
dc.creator.none.fl_str_mv Montemurro, Nicola
Postigo, Cristina
Lonigro, Antonio
Pérez Solsona, Sandra
Barceló, Damià
author Montemurro, Nicola
author_facet Montemurro, Nicola
Postigo, Cristina
Lonigro, Antonio
Pérez Solsona, Sandra
Barceló, Damià
author_role author
author2 Postigo, Cristina
Lonigro, Antonio
Pérez Solsona, Sandra
Barceló, Damià
author2_role author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Illicit drugs
Liquid chromatography–mass spectrometry
Online solid-phase extraction
Pharmaceuticals
Plant uptake
Ultrasound extraction
topic Illicit drugs
Liquid chromatography–mass spectrometry
Online solid-phase extraction
Pharmaceuticals
Plant uptake
Ultrasound extraction
description We present an analytical method developed and validated to study the potential uptake of 13 selected drugs (ten pharmaceuticals, one illicit drug, and two transformation products) into lettuce plants from contaminated water and soil. Some of the selected drugs (i.e., cocaine, methadone, cis-diltiazem, valsartan, and valsartan acid), which are commonly present in treated wastewater, were investigated for the first time in plant tissues. The method is based on ultrasonic solvent extraction with acetonitrile–methanol (1:1, v/v) and subsequent automated extract cleanup and analysis by means of online solid-phase extraction–liquid chromatography–tandem mass spectrometry. Optimum extraction conditions were selected after evaluation of analyte recoveries with four different extraction techniques (ultrasonic solvent extraction, solid–liquid extraction, pressurized liquid extraction, and a “quick, easy, cheap, effective, rugged, and safe” based method) and six different solvent mixtures. Furthermore, two different solid-phase extraction cleanup sorbents were evaluated. The method developed has high sensitivity (with limits of detection between 0.1 and 12.6 ng per gram dry weight and limits of quantification between 0.5 and 42.0 ng per gram dry weight), satisfactory accuracy (with analyte relative recoveries above 80% for all analytes but acridone and oxcarbazepine), and good repeatability (with relative standard deviations below 9% for all analytes). As part of the validation procedure, the analytical method was applied to the analysis of lettuce plants irrigated with water fortified with the selected compounds for the entire growing period. The results obtained evidenced the transfer of all the investigated drugs into lettuce leaves. [Figure not available: see fulltext.] © 2017 Springer-Verlag Berlin Heidelberg
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/152206
url http://hdl.handle.net/10261/152206
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/603437
10.1007/s00216-017-0363-1
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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