Naproxen: Hydroxypropyl-β-cyclodextrin: Polyvinylpyrrolidone ternary complex formation
[EN]The aim of the present study was to investigate the effect of the presence of the water-soluble polymer polyvinylpyrrolidone (PVP) MW = 24000 g/mol, on the complexation of the phototoxic anti-inflammatory drug naproxen, in its sodium salt form, with hydroxypropil-β-cyclodextrin (HP-β-CD). The da...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2004 |
| País: | España |
| Institución: | Universidad de Salamanca (USAL) |
| Repositorio: | GREDOS. Repositorio Institucional de la Universidad de Salamanca |
| OAI Identifier: | oai:dnet:gredos______::9dfe1f370c6d176339c6ca7c4bcff04b |
| Acceso en línea: | http://hdl.handle.net/10366/171080 |
| Access Level: | acceso abierto |
| Palabra clave: | Naproxen Hydroxypropyl-β-cyclodextrin Polyvinylpyrrolidone Ternary complex Ternary Complex Factors naproxeno factores complejos ternarios |
| Sumario: | [EN]The aim of the present study was to investigate the effect of the presence of the water-soluble polymer polyvinylpyrrolidone (PVP) MW = 24000 g/mol, on the complexation of the phototoxic anti-inflammatory drug naproxen, in its sodium salt form, with hydroxypropil-β-cyclodextrin (HP-β-CD). The data show that the polymer interacts with the free naproxen and with the naproxen:HP-β-CD inclusion complex. The presence of different proportions of PVP, in the 0–1%(w/w) range systematically increased the Kapp of the naproxen:HP-β-CDinclusion complex formation. The cause of this increase is that the polymer interacts with the HP-β-CD with a binding constant of K2 = 29000± 53M−1; and with the naproxen:HP-β-CD inclusion complex, to give a ternary complex naproxen:HP-β-CD:PVP. The binding constant of this process was K3 = 5350 ± 1 M−1. NMR data revealed that in the ternary system, PVP is outside of the cyclodextrin, and therefore must be wholly or partially recovering the naproxen:HP-β-CD inclusion complex. |
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